. . . . . . . . . . . . . . . . . . "HIV-1 group N and group O Nef alleles only weakly downregulate CD4, CD28, and class I and II MHC molecules" . "Nef-triggered MHCII endocytosis requires Rab5 activity and lyst function, whereas lysosomal trafficking of internalized MHCII molecules requires Rab7 activity" . "HIV-1 Nef expression inhibits MHC II presentation of viral antigens in infected antigen-presenting cells" . "Expression of patient-derived HIV-1 nef alleles downregulates MHC-II cell surface expression in activated CD4+ T cells" . "inhibits" . "downregulates" .