. . . . . . . . . . . . "HIV-1 Nef colocalizes with CD8-CD3 zeta on the HEK293 cell surface" . "\u009D-COP as a cellular cofactor is required for HIV-1 Nef-mediated HLA-A2, CD4, and CD8 downregulation" . "HIV-inoculated and HIV-1 Nef-treated human peripheral blood lymphocytes downregulate cell surface CD8, and this down-modulation could inhibit anti-HIV cytotoxicity associated with cytotoxic T-cell function" . "downregulates" . "colocalizes with" .