. . . . . . . "HIV-1 Nef myristoylation is required for the rapid and transient phosphorylation of the alpha- and beta- subunits of the Ikappa-B kinase complex and activation of JNK, ERK1/2 and p38 MAPK family members" . "Nef inhibits ASK1/p38MAPK-dependent Mycobacterium tuberculosis-induced TNF-alpha production by inhibiting binding of ATF2 to the TNF-alpha promoter" . "HIV-1 Nef-induced programmed death 1 (PD-1) upregulation requires its proline-rich motif and the activation of the downstream kinase p38" . "HIV-1 Nef induces phosphorylation of p38 MAPK in M2-type macrophages" . "inhibits" . "induces phosphorylation of" . "regulated by" . "activates" .