. . . . . "HIV-1 Tat may function as an adaptor molecule, efficiently stimulating the processes of transcription initiation and elongation through potentiation of the coupling of p160 co-activators and the P-TEFb complex" . "p/CIP binds to HIV-1 Tat and enhances Tat-stimulated HIV-1 LTR promoter transactivation" . "NCOA3 is downregulated in HIV-1 Tat and NC cotransfection of HEK 293T cells" . "downregulates" . "stimulates" . "enhanced by" .