<http://identifiers.org/uniprot/Q9Z0X4> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#ProteinReference> .
<http://identifiers.org/uniprot/Q9Z0X4> <http://www.biopax.org/release/biopax-level3.owl#comment> "SEQUENCE 1141 AA; 124513 MW; 3D9ACCFF928219D8 CRC64;"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q9Z0X4> <http://www.biopax.org/release/biopax-level3.owl#comment> "FUNCTION: Cyclic nucleotide phosphodiesterase with a dual- specificity for the second messengers cAMP and cGMP, which are key regulators of many important physiological processes. Involved in oocyte maturation. CATALYTIC ACTIVITY: Nucleoside 3',5'-cyclic phosphate + H(2)O = nucleoside 5'-phosphate. COFACTOR: Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions (By similarity). ENZYME REGULATION: Inhibited by cGMP (By similarity). BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=0.2 uM for cAMP; SUBCELLULAR LOCATION: Membrane; Multi-pass membrane protein (Potential). SIMILARITY: Belongs to the cyclic nucleotide phosphodiesterase family. PDE3 subfamily. GENE SYNONYMS:Pde3a. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q9Z0X4> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:REFSEQ_NP_061249> .
<http://identifiers.org/uniprot/Q9Z0X4> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:NCBI+GENE_54611> .
<http://identifiers.org/uniprot/Q9Z0X4> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q9Z0X4> .
<http://identifiers.org/uniprot/Q9Z0X4> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:MOUSE+GENOME+DATABASE_MGI%3A1860764> .
<http://identifiers.org/uniprot/Q9Z0X4> <http://www.biopax.org/release/biopax-level3.owl#displayName> "PDE3A_MOUSE"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q9Z0X4> <http://www.biopax.org/release/biopax-level3.owl#name> "3.1.4.17"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q9Z0X4> <http://www.biopax.org/release/biopax-level3.owl#name> "Cyclic GMP-inhibited phosphodiesterase A"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q9Z0X4> <http://www.biopax.org/release/biopax-level3.owl#name> "Pde3a"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q9Z0X4> <http://www.biopax.org/release/biopax-level3.owl#name> "CGI-PDE A"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q9Z0X4> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:PDE3A_MOUSE_2> .
<http://identifiers.org/uniprot/Q9Z0X4> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:PDE3A_MOUSE_4> .
<http://identifiers.org/uniprot/Q9Z0X4> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:PDE3A_MOUSE_3> .
<http://identifiers.org/uniprot/Q9Z0X4> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:PDE3A_MOUSE_1> .
<http://identifiers.org/uniprot/Q9Z0X4> <http://www.biopax.org/release/biopax-level3.owl#organism> <http://identifiers.org/taxonomy/10090> .
<http://identifiers.org/uniprot/Q9Z0X4> <http://www.biopax.org/release/biopax-level3.owl#sequence> "MAVRGEAAQDLAKPGLGGASPARVARGNHRHRGESSPSPRGSGCCWRALALQPLRRSPQLSSALCAGSLSVLLALLVRLVGGEVGGELEKSQEAAAEEEEEEGARGGVFPGPRGGAPGGGAQLSPWLQPAALLFSLLCAFFWMGLCLLRAGVRLPLAVALLAACCAGEALVQLSLGVGDGRLLSLPAAGVLLSCLGGATWLVLRLRLGVLMVAWTSVLRTVALVSLERFKVAWRPYLAYLAAVLGLLLARYAEQILPQCSGPAPPRERFGSQLSARTKEEIPGWKRRRRSSSVVAGEMSGCSGKSHRRTSLPCIPREQLMGHSEWDHKRGPRGSQSGTSITVDIAVMGEAHGLITDLLADPSLPPNVCTSLRAVSNLLSTQLTFQAIHKPRVNPTVTFSENYTCSDSEEGLEKDKQAISKRLRRSLPPGLLRRVSSTWTTTTSATGLPTLEPAPVRRDRSASIKPHEAPSPSAVNPDSWNAPGLTTLTKSRSFTSSYAVSAANHVKAKKQNRPGGLAKISPVPSPSSSPPQGSPASSPVSNSASQQFPESPEVTIKRGPGSHRALTYTQSAPDLSPQIPPPSVICSSCGRPYSQGNPADGPSERSGPAMLKPNRTDDTSQVTSDYETNNNSDSSDILQNEEEAECQREPQRKASACGTYTSQTMIFLDKPILAPEPLVMDNLDSIMDQLNTWNFPIFDLMENIGRKCGRILSQVSYRLFEDMGLFEAFKIPVREFMNYFHALEIGYRDIPYHNRIHATDVLHAVWYLTTQPIPGLPSVIGDHGSASDSDSDSGFTHGHMGYVFSKMYHVPDDKYGCLSGNIPALELMALYVAAAMHDYDHPGRTNAFLVATSAPQAVLYNDRSVLENHHAAAAWNLFMSRPEYNFLVNLDHVEFKHFRFLVIEAILATDLKKHFDFVAKFNAKVNDDVGIDWTNENDRLLVCQMCIKLADINGPAKCKELHLRWTEGIASEFYEQGDEEASLGLPISPFMDRSAPQLANLQESFISHIVGPLCHSYDSAGLMPGKWVDDSDDSGDTDDPEEEEEEAETPHEDEACESSIAPRKKSFKRRRIYCQITQHLLQNHMMWKKVIEEEQCLSGTENQSLDQVPLQHPSEQIQAIKEEEEEKGKPRAEETLAPQPDL"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q9Z0X4> <http://www.biopax.org/release/biopax-level3.owl#standardName> "cGMP-inhibited 3',5'-cyclic phosphodiesterase A"^^<http://www.w3.org/2001/XMLSchema#string> .