<http://identifiers.org/uniprot/Q9Y613> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#ProteinReference> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#comment> "SEQUENCE 1164 AA; 126551 MW; E6C7AE1FB8DC3FC7 CRC64;"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#comment> "FUNCTION: Required for the assembly of F-actin structures, such as stress fibers. Depends on the Rho-ROCK cascade for its activity. Contributes to the coordination of microtubules with actin fibers and plays a role in cell elongation. Acts synergistically with ROCK1 to promote SRC-dependent non-apoptotic plasma membrane blebbing. SUBUNIT: Self-associates via the FH2 domain. Binds to F-actin via its N-terminus. Binds to the cytoplasmic domain of CD21 via its C- terminus. Interacts with ROCK1 in a Src-dependent manner. SUBCELLULAR LOCATION: Cytoplasm. Cytoplasm, cytoskeleton. Cell projection, bleb. Note=Predominantly cytoplasmic. TISSUE SPECIFICITY: Ubiquitous. Highly expressed in spleen. DOMAIN: The DAD domain regulates activation via by an autoinhibitory interaction with the GBD/FH3 domain. This autoinhibition is released upon competitive binding of an activated GTPase. The release of DAD allows the FH2 domain to then nucleate and elongate nonbranched actin filaments. PTM: Phosphorylated by ROCK1. SIMILARITY: Belongs to the formin homology family. SIMILARITY: Contains 1 DAD (diaphanous autoregulatory) domain. SIMILARITY: Contains 1 FH1 (formin homology 1) domain. SIMILARITY: Contains 1 FH2 (formin homology 2) domain. SIMILARITY: Contains 1 GBD/FH3 (Rho GTPase-binding/formin homology 3) domain. GENE SYNONYMS:FHOD1 FHOS FHOS1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q8N521> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q59F76> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:REFSEQ_NP_037373> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q76MS8> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q6Y1F2> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q9Y613> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:NCBI+GENE_29109> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:HGNC_HGNC%3A17905> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#displayName> "FHOD1_HUMAN"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#name> "Formin homology 2 domain-containing protein 1"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#name> "Formin homolog overexpressed in spleen 1"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#name> "FHOS"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#name> "FHOD1"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:FHOD1_HUMAN_1> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:FHOD1_HUMAN_4> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:FHOD1_HUMAN_2> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:FHOD1_HUMAN_6> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:FHOD1_HUMAN_5> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:FHOD1_HUMAN_7> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:FHOD1_HUMAN_3> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#organism> <http://identifiers.org/taxonomy/9606> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#sequence> "MAGGEDRGDGEPVSVVTVRVQYLEDTDPFACANFPEPRRAPTCSLDGALPLGAQIPAVHRLLGAPLKLEDCALQVSPSGYYLDTELSLEEQREMLEGFYEEISKGRKPTLILRTQLSVRVNAILEKLYSSSGPELRRSLFSLKQIFQEDKDLVPEFVHSEGLSCLIRVGAAADHNYQSYILRALGQLMLFVDGMLGVVAHSDTIQWLYTLCASLSRLVVKTALKLLLVFVEYSENNAPLFIRAVNSVASTTGAPPWANLVSILEEKNGADPELLVYTVTLINKTLAALPDQDSFYDVTDALEQQGMEALVQRHLGTAGTDVDLRTQLVLYENALKLEDGDIEEAPGAGGRRERRKPSSEEGKRSRRSLEGGGCPARAPEPGPTGPASPVGPTSSTGPALLTGPASSPVGPPSGLQASVNLFPTISVAPSADTSSERSIYKARFLENVAAAETEKQVALAQGRAETLAGAMPNEAGGHPDARQLWDSPETAPAARTPQSPAPCVLLRAQRSLAPEPKEPLIPASPKAEPIWELPTRAPRLSIGDLDFSDLGEDEDQDMLNVESVEAGKDIPAPSPPLPLLSGVPPPPPLPPPPPIKGPFPPPPPLPLAAPLPHSVPDSSALPTKRKTVKLFWRELKLAGGHGVSASRFGPCATLWASLDPVSVDTARLEHLFESRAKEVLPSKKAGEGRRTMTTVLDPKRSNAINIGLTTLPPVHVIKAALLNFDEFAVSKDGIEKLLTMMPTEEERQKIEEAQLANPDIPLGPAENFLMTLASIGGLAARLQLWAFKLDYDSMEREIAEPLFDLKVGMEQLVQNATFRCILATLLAVGNFLNGSQSSGFELSYLEKVSEVKDTVRRQSLLHHLCSLVLQTRPESSDLYSEIPALTRCAKVDFEQLTENLGQLERRSRAAEESLRSLAKHELAPALRARLTHFLDQCARRVAMLRIVHRRVCNRFHAFLLYLGYTPQAAREVRIMQFCHTLREFALEYRTCRERVLQQQQKQATYRERNKTRGRMITETEKFSGVAGEAPSNPSVPVAVSSGPGRGDADSHASMKSLLTSRPEDTTHNRRSRGMVQSSSPIMPTVGPSTASPEEPPGSSLPSDTSDEIMDLLVQSVTKSSPRALAARERKRSRGNRKSLRRTLKSGLGDDLVQALGLSKGPGLEV"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q9Y613> <http://www.biopax.org/release/biopax-level3.owl#standardName> "FH1/FH2 domain-containing protein 1"^^<http://www.w3.org/2001/XMLSchema#string> .