. "SEQUENCE 359 AA; 40308 MW; 2E02D47F4F98592F CRC64;"^^ . "FUNCTION: Produces N-acetylneuraminic acid (Neu5Ac) and 2-keto-3- deoxy-D-glycero-D-galacto-nononic acid (KDN). Can also use N- acetylmannosamine 6-phosphate and mannose 6-phosphate as substrates to generate phosphorylated forms of Neu5Ac and KDN, respectively. CATALYTIC ACTIVITY: Phosphoenolpyruvate + N-acetyl-D-mannosamine + H(2)O = phosphate + N-acetylneuraminate. CATALYTIC ACTIVITY: Phosphoenolpyruvate + N-acyl-D-mannosamine 6- phosphate + H(2)O = N-acylneuraminate 9-phosphate + phosphate. TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Contains 1 AFP-like domain. GENE SYNONYMS:NANS SAS. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^ . . . . . . . . . "SIAS_HUMAN"^^ . "2.5.1.56"^^ . "2.5.1.57"^^ . "N-acetylneuraminic acid synthase"^^ . "N-acetylneuraminate-9-phosphate synthase"^^ . "N-acetylneuraminate synthase"^^ . "N-acetylneuraminic acid phosphate synthase"^^ . "NANS"^^ . . . "MPLELELCPGRWVGGQHPCFIIAEIGQNHQGDLDVAKRMIRMAKECGADCAKFQKSELEFKFNRKALERPYTSKHSWGKTYGEHKRHLEFSHDQYRELQRYAEEVGIFFTASGMDEMAVEFLHELNVPFFKVGSGDTNNFPYLEKTAKKGRPMVISSGMQSMDTMKQVYQIVKPLNPNFCFLQCTSAYPLQPEDVNLRVISEYQKLFPDIPIGYSGHETGIAISVAAVALGAKVLERHITLDKTWKGSDHSASLEPGELAELVRSVRLVERALGSPTKQLLPCEMACNEKLGKSVVAKVKIPEGTILTMDMLTVKVGEPKGYPPEDIFNLVGKKVLVTVEEDDTIMEELVDNHGKKIKS"^^ . "Sialic acid synthase"^^ .