. "SEQUENCE 328 AA; 38136 MW; 10A7393B607117EB CRC64;"^^ . "FUNCTION: Regulatory protein which represses transcription and augments histone deacetylase activity of HDAC1. May have a potential role in tumor suppressor pathways (By similarity). May function in the assembly and/or enzymatic activity of the mSin3A corepressor complex or in mediating interactions between the complex and other regulatory complexes. SUBUNIT: Homodimer. Component of the SIN3 histone deacetylase (HDAC) corepressor complex. Interacts with SIN3A. Interaction with SIN3B enhances the interaction between SIN3B and HDAC1 to form a complex (By similarity). Interacts with HCFC1. Component of a mSin3A corepressor complex that contains SIN3A, SAP130, SUDS3/SAP45, ARID4B/SAP180, HDAC1 and HDAC2. TISSUE SPECIFICITY: Expressed in various cancer cell ines. DOMAIN: The C-terminus is involved in transcriptional repression by HDAC-independent mechanisms. SIMILARITY: Belongs to the SDS3 family. SEQUENCE CAUTION: Sequence=BAB14685.1; Type=Erroneous initiation; Sequence=BAB15750.1; Type=Erroneous initiation; GENE SYNONYMS:SUDS3 SAP45 SDS3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^ . . . . . . . . "SDS3_HUMAN"^^ . "45 kDa Sin3-associated polypeptide"^^ . "Suppressor of defective silencing 3 protein homolog"^^ . "SUDS3"^^ . . . . . . . . . . "MSAAGLLAPAPAQAGAPPAPEYYPEEDEELESAEDDERSCRGRESDEDTEDASETDLAKHDEEDYVEMKEQMYQDKLASLKRQLQQLQEGTLQEYQKRMKKLDQQYKERIRNAELFLQLETEQVERNYIKEKKAAVKEFEDKKVELKENLIAELEEKKKMIENEKLTMELTGDSMEVKPIMTRKLRRRPNDPVPIPDKRRKPAPAQLNYLLTDEQIMEDLRTLNKLKSPKRPASPSSPEHLPATPAESPAQRFEARIEDGKLYYDKRWYHKSQAIYLESKDNQKLSCVISSVGANEIWVRKTSDSTKMRIYLGQLQRGLFVIRRRSAA"^^ . "Sin3 histone deacetylase corepressor complex component SDS3"^^ .