. "FUNCTION: Binds to activated (phosphorylated) protein-tyrosine kinases through its SH2 domain and regulates their kinase activity. During insulin stimulation, it also binds to IRS-1. SUBUNIT: Heterodimer of a regulatory subunit PIK3R3 and a p110 catalytic subunit (PIK3CA, PIK3CB or PIK3CD). Interacts with AXL (By similarity). TISSUE SPECIFICITY: Highest levels in brain and testis. Lower levels in adipose tissue, kidney, heart, lung and skeletal muscle. Barely detectable in liver and spleen. SIMILARITY: Belongs to the PI3K p85 subunit family. SIMILARITY: Contains 2 SH2 domains. GENE SYNONYMS:Pik3r3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^ . "SEQUENCE 461 AA; 54254 MW; 6467D88447CC562B CRC64;"^^ . . . . . "P55G_RAT"^^ . "PI3-kinase regulatory subunit gamma"^^ . "PtdIns-3-kinase regulatory subunit gamma"^^ . "Pik3r3"^^ . "p55PIK"^^ . "PI3K regulatory subunit gamma"^^ . "PI3-kinase subunit p55-gamma"^^ . "Phosphatidylinositol 3-kinase 55 kDa regulatory subunit gamma"^^ . "PtdIns-3-kinase regulatory subunit p55-gamma"^^ . . . . "MYNTVWSMDRDDADWREVMMPYSTELIFYIEMDPPALPPKPPKPVTSAVTNGMKDCFVSLQDAEWYWGDISREEVNDKLRDMPDGTFLVRDASTKMQGDYTLTLRKGGNNKLIKIYHRDGNYGFSEPLTFNSVVELINHYHHESLAQYNPKLDVKLMYPVSRYQQDQLVKEDNIDAVGKNLQEFHSQYQEKSKEYDRLYEEYTRTSQEIQMKRTAIEAFNETIKIFEEQCHTQEQHSKDYIERFRREGNEKEIERIMMNYDKLKSRLGEIHDSKVRLEQDLKKQALDNREIDKKMNSIKPDLIQLRKIRDQHLVWLNHRGVRQRRLNAWLGIKSEDTDESYFINEDDESLPHYDEKTWFVEDVNRVQAEDLLYGKPDGAFLIRESSKKGCYACSVVADGEVKPCVIYSPARGYGFAEPYNLYGSLKELVLHYQQTSLVQHNDSLNVTLAYPVHAQMPSLCR"^^ . "Phosphatidylinositol 3-kinase regulatory subunit gamma"^^ .