. "SEQUENCE 192 AA; 21995 MW; D7E720D0DDCCA249 CRC64;"^^ . "CATALYTIC ACTIVITY: ATP + (R)-5-phosphomevalonate = ADP + (R)-5- diphosphomevalonate. BIOPHYSICOCHEMICAL PROPERTIES: Kinetic parameters: KM=25 uM for (R)-5-phosphomevalonate; KM=0.26 mM for ATP; Vmax=46.4 umol/min/mg enzyme with (R)-5-phosphomevalonate as substrate; Vmax=52 umol/min/mg enzyme with ATP as substrate; PATHWAY: Isoprenoid biosynthesis; isopentenyl diphosphate biosynthesis via mevalonate pathway; isopentenyl diphosphate from (R)-mevalonate: step 2/3. SUBUNIT: Monomer (By similarity). SUBCELLULAR LOCATION: Peroxisome. TISSUE SPECIFICITY: Heart, liver, skeletal muscle, kidney, and pancreas. Lower level in brain, placenta and lung. INDUCTION: By sterol. GENE SYNONYMS:PMVK PMKI. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^ . . . . . . "PMVK_HUMAN"^^ . "2.7.4.2"^^ . "PMKase"^^ . "hPMK"^^ . "PMVK"^^ . . "MAPLGGAPRLVLLFSGKRKSGKDFVTEALQSRLGADVCAVLRLSGPLKEQYAQEHGLNFQRLLDTSTYKEAFRKDMIRWGEEKRQADPGFFCRKIVEGISQPIWLVSDTRRVSDIQWFREAYGAVTQTVRVVALEQSRQQRGWVFTPGVDDAESECGLDNFGDFDWVIENHGVEQRLEEQLENLIEFIRSRL"^^ . "Phosphomevalonate kinase"^^ .