. "FUNCTION: RNA-binding protein. Possesses nucleolytic activity against cytotoxic lymphocyte target cells. May be involved in apoptosis. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). Cytoplasmic granule. Note=The cytoplasmic granules are stress granules which are a dense aggregation in the cytosol composed of proteins and RNAs that appear when the cell is under stress. Co-localizes with NANOS3 in the stress granules (By similarity). Cytoplasmic granules of cytolytic T-lymphocytes. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q01085-1; Sequence=Displayed; Name=2; IsoId=Q01085-2; Sequence=VSP_043700; Note=No experimental confirmation available; PTM: Phosphorylated by MAPK14 following DNA damage, releasing TIAR from GADD45A mRNA. SIMILARITY: Contains 3 RRM (RNA recognition motif) domains. GENE SYNONYMS:TIAL1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^ . "SEQUENCE 375 AA; 41591 MW; 2F8D1C7169A7817E CRC64;"^^ . . . . . . . . "TIAR_HUMAN"^^ . "TIAL1"^^ . "TIA-1-related protein"^^ . . . . . "MMEDDGQPRTLYVGNLSRDVTEVLILQLFSQIGPCKSCKMITEHTSNDPYCFVEFYEHRDAAAALAAMNGRKILGKEVKVNWATTPSSQKKDTSNHFHVFVGDLSPEITTEDIKSAFAPFGKISDARVVKDMATGKSKGYGFVSFYNKLDAENAIVHMGGQWLGGRQIRTNWATRKPPAPKSTQENNTKQLRFEDVVNQSSPKNCTVYCGGIASGLTDQLMRQTFSPFGQIMEIRVFPEKGYSFVRFSTHESAAHAIVSVNGTTIEGHVVKCYWGKESPDMTKNFQQVDYSQWGQWSQVYGNPQQYGQYMANGWQVPPYGVYGQPWNQQGFGVDQSPSAAWMGGFGAQPPQGQAPPPVIPPPNQAGYGMASYQTQ"^^ . "Nucleolysin TIAR"^^ .