. "SEQUENCE 119 AA; 13715 MW; AFD2DBEF07DCEF27 CRC64;"^^ . "FUNCTION: Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. SUBUNIT: Heterodimer of an alpha chain and a beta chain. Beta-2- microglobulin is the beta-chain of major histocompatibility complex class I molecules. Polymers of beta 2-microglobulin can be found in tissues from patients on long-term hemodialysis. SUBCELLULAR LOCATION: Secreted. Note=Detected in serum and urine. PTM: Glycation of Ile-21 is observed in long-term hemodialysis patients. DISEASE: Defects in B2M are the cause of hypercatabolic hypoproteinemia (HYCATHYP) [MIM:241600]. Affected individuals show marked reduction in serum concentrations of immunoglobulin and albumin, probably due to rapid degradation. DISEASE: Note=Beta-2-microglobulin may adopt the fibrillar configuration of amyloid in certain pathologic states. The capacity to assemble into amyloid fibrils is concentration dependent. Persistently high beta(2)-microglobulin serum levels lead to amyloidosis in patients on long-term hemodialysis. SIMILARITY: Belongs to the beta-2-microglobulin family. SIMILARITY: Contains 1 Ig-like C1-type (immunoglobulin-like) domain. WEB RESOURCE: Name=Wikipedia; Note=Beta-2-microglobulin entry; URL=\"http://en.wikipedia.org/wiki/Beta-2-microglobulin\"; GENE SYNONYMS:B2M. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^ . . . . . . . . . . . "B2MG_HUMAN"^^ . "B2M"^^ . "Beta-2-microglobulin form pI 5.3"^^ . . . "MSRSVALAVLALLSLSGLEAIQRTPKIQVYSRHPAENGKSNFLNCYVSGFHPSDIEVDLLKNGERIEKVEHSDLSFSKDWSFYLLYYTEFTPTEKDEYACRVNHVTLSQPKIVKWDRDM"^^ . "Beta-2-microglobulin"^^ .