. "FUNCTION: Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. SUBUNIT: Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. Binds to the C-terminal part of VHL. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=In complex with VHL can translocate to the nucleus. TISSUE SPECIFICITY: Ubiquitous. SIMILARITY: Belongs to the prefoldin subunit alpha family. SEQUENCE CAUTION: Sequence=AAC23907.1; Type=Erroneous initiation; GENE SYNONYMS:VBP1 PFDN3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^ . "SEQUENCE 197 AA; 22658 MW; 973BBDE2B3903E39 CRC64;"^^ . . . . . . . . . . "PFD3_HUMAN"^^ . "VBP1"^^ . "VBP-1"^^ . "VHL-binding protein 1"^^ . "Von Hippel-Lindau-binding protein 1"^^ . "HIBBJ46"^^ . . . "MAAVKDSCGKGEMATGNGRRLHLGIPEAVFVEDVDSFMKQPGNETADTVLKKLDEQYQKYKFMELNLAQKKRRLKGQIPEIKQTLEILKYMQKKKESTNSMETRFLLADNLYCKASVPPTDKMCLWLGANVMLEYDIDEAQALLEKNLSTATKNLDSLEEDLDFLRDQFTTTEVNMARVYNWDVKRRNKDDSTKNKA"^^ . "Prefoldin subunit 3"^^ .