. "SEQUENCE 418 AA; 46441 MW; B7719FCA13A55DEB CRC64;"^^ . "FUNCTION: Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. SUBCELLULAR LOCATION: Endoplasmic reticulum lumen. INDUCTION: By heat shock. POLYMORPHISM: A functional SNP in the promoter of SERPINH1 is associated in African Americans with an increased risk for preterm premature rupture of membranes (PPROM) [MIM:610504]. PPROM is defined as rupture of the membranes before 37 weeks of gestation. SERPINH1 with the -656 T allele displays significantly reduced promoter activity compared to the major -656 C allele. Prematurity is correlated with an increased frequency of the -656 T allele. DISEASE: Defects in SERPINH1 are the cause of osteogenesis imperfecta type 10 (OI10) [MIM:613848]. A connective tissue disorder characterized by bone fragility, low bone mass, bowing of limbs due to multiple fractures, short limb dwarfism and blue sclerae. SIMILARITY: Belongs to the serpin family. WEB RESOURCE: Name=Osteogenesis imperfecta variant database; Note=Serpin H1 (SERPINH1); URL=\"http://oi.gene.le.ac.uk/home.php?select_db=SERPINH1\"; GENE SYNONYMS:SERPINH1 CBP1 CBP2 HSP47 SERPINH2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^ . . . . . . . . . . . . "SERPH_HUMAN"^^ . "Arsenic-transactivated protein 3"^^ . "47 kDa heat shock protein"^^ . "Collagen-binding protein"^^ . "Rheumatoid arthritis-related antigen RA-A47"^^ . "Colligin"^^ . "SERPINH1"^^ . "AsTP3"^^ . "Cell proliferation-inducing gene 14 protein"^^ . . "MRSLLLLSAFCLLEAALAAEVKKPAAAAAPGTAEKLSPKAATLAERSAGLAFSLYQAMAKDQAVENILVSPVVVASSLGLVSLGGKATTASQAKAVLSAEQLRDEEVHAGLGELLRSLSNSTARNVTWKLGSRLYGPSSVSFADDFVRSSKQHYNCEHSKINFRDKRSALQSINEWAAQTTDGKLPEVTKDVERTDGALLVNAMFFKPHWDEKFHHKMVDNRGFMVTRSYTVGVMMMHRTGLYNYYDDEKEKLQIVEMPLAHKLSSLIILMPHHVEPLERLEKLLTKEQLKIWMGKMQKKAVAISLPKGVVEVTHDLQKHLAGLGLTEAIDKNKADLSRMSGKKDLYLASVFHATAFELDTDGNPFDQDIYGREELRSPKLFYADHPFIFLVRDTQSGSLLFIGRLVRPKGDKMRDEL"^^ . "Serpin H1"^^ .