. "SEQUENCE 286 AA; 32556 MW; 4DA6AC20FC6EC885 CRC64;"^^ . "FUNCTION: Catalyzes the oxidative ring opening of 3- hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate. CATALYTIC ACTIVITY: 3-hydroxyanthranilate + O(2) = 2-amino-3- carboxymuconate semialdehyde. COFACTOR: Fe(2+) ion. PATHWAY: Cofactor biosynthesis; NAD(+) biosynthesis; quinolinate from L-kynurenine: step 3/3. SUBUNIT: Monomer. SUBCELLULAR LOCATION: Cytoplasm. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=P46952-1; Sequence=Displayed; Name=2; IsoId=P46952-2; Sequence=VSP_036239; SIMILARITY: Belongs to the 3-HAO family. GENE SYNONYMS:HAAO. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^ . . . . . . . . . "3HAO_HUMAN"^^ . "3-hydroxyanthranilic acid dioxygenase"^^ . "3-hydroxyanthranilate oxygenase"^^ . "HAAO"^^ . "1.13.11.6"^^ . "HAD"^^ . "3-HAO"^^ . . "MERRLGVRAWVKENRGSFQPPVCNKLMHQEQLKVMFIGGPNTRKDYHIEEGEEVFYQLEGDMVLRVLEQGKHRDVVIRQGEIFLLPARVPHSPQRFANTVGLVVERRRLETELDGLRYYVGDTMDVLFEKWFYCKDLGTQLAPIIQEFFSSEQYRTGKPIPDQLLKEPPFPLSTRSIMEPMSLDAWLDSHHRELQAGTPLSLFGDTYETQVIAYGQGSSEGLRQNVDVWLWQLEGSSVVTMGGRRLSLAPDDSLLVLAGTSYAWERTQGSVALSVTQDPACKKPLG"^^ . "3-hydroxyanthranilate 3,4-dioxygenase"^^ .