<http://identifiers.org/uniprot/P42685> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#ProteinReference> .
<http://identifiers.org/uniprot/P42685> <http://www.biopax.org/release/biopax-level3.owl#comment> "FUNCTION: Non-receptor tyrosine-protein kinase that negatively regulates cell proliferation. Positively regulates PTEN protein stability through phosphorylation of PTEN on 'Tyr-336', which in turn prevents its ubiquitination and degradation, possibly by reducing its binding to NEDD4. May function as a tumor suppressor. CATALYTIC ACTIVITY: ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate. SUBUNIT: Interacts (via the SH3-domain) with PTEN. Interacts with RB1. SUBCELLULAR LOCATION: Cytoplasm. Nucleus. Note=Predominantly found in the nucleus, with a small fraction found in the cell periphery. TISSUE SPECIFICITY: Predominantly expressed in epithelial derived cell lines and tissues, especially normal liver, kidney, breast and colon. SIMILARITY: Belongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily. SIMILARITY: Contains 1 protein kinase domain. SIMILARITY: Contains 1 SH2 domain. SIMILARITY: Contains 1 SH3 domain. GENE SYNONYMS:FRK PTK5 RAK. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P42685> <http://www.biopax.org/release/biopax-level3.owl#comment> "SEQUENCE 505 AA; 58254 MW; 06EC050DDBCD930B CRC64;"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P42685> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q13128> .
<http://identifiers.org/uniprot/P42685> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:HGNC_HGNC%3A3955> .
<http://identifiers.org/uniprot/P42685> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:NCBI+GENE_2444> .
<http://identifiers.org/uniprot/P42685> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q9NTR5> .
<http://identifiers.org/uniprot/P42685> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_P42685> .
<http://identifiers.org/uniprot/P42685> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:REFSEQ_NP_002022> .
<http://identifiers.org/uniprot/P42685> <http://www.biopax.org/release/biopax-level3.owl#displayName> "FRK_HUMAN"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P42685> <http://www.biopax.org/release/biopax-level3.owl#name> "2.7.10.2"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P42685> <http://www.biopax.org/release/biopax-level3.owl#name> "FRK"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P42685> <http://www.biopax.org/release/biopax-level3.owl#name> "FYN-related kinase"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P42685> <http://www.biopax.org/release/biopax-level3.owl#name> "Nuclear tyrosine protein kinase RAK"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P42685> <http://www.biopax.org/release/biopax-level3.owl#name> "Protein-tyrosine kinase 5"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P42685> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:FRK_HUMAN_5> .
<http://identifiers.org/uniprot/P42685> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:FRK_HUMAN_4> .
<http://identifiers.org/uniprot/P42685> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:FRK_HUMAN_2> .
<http://identifiers.org/uniprot/P42685> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:FRK_HUMAN_3> .
<http://identifiers.org/uniprot/P42685> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:FRK_HUMAN_1> .
<http://identifiers.org/uniprot/P42685> <http://www.biopax.org/release/biopax-level3.owl#organism> <http://identifiers.org/taxonomy/9606> .
<http://identifiers.org/uniprot/P42685> <http://www.biopax.org/release/biopax-level3.owl#sequence> "MSNICQRLWEYLEPYLPCLSTEADKSTVIENPGALCSPQSQRHGHYFVALFDYQARTAEDLSFRAGDKLQVLDTLHEGWWFARHLEKRRDGSSQQLQGYIPSNYVAEDRSLQAEPWFFGAIGRSDAEKQLLYSENKTGSFLIRESESQKGEFSLSVLDGAVVKHYRIKRLDEGGFFLTRRRIFSTLNEFVSHYTKTSDGLCVKLGKPCLKIQVPAPFDLSYKTVDQWEIDRNSIQLLKRLGSGQFGEVWEGLWNNTTPVAVKTLKPGSMDPNDFLREAQIMKNLRHPKLIQLYAVCTLEDPIYIITELMRHGSLQEYLQNDTGSKIHLTQQVDMAAQVASGMAYLESRNYIHRDLAARNVLVGEHNIYKVADFGLARVFKVDNEDIYESRHEIKLPVKWTAPEAIRSNKFSIKSDVWSFGILLYEIITYGKMPYSGMTGAQVIQMLAQNYRLPQPSNCPQQFYNIMLECWNAEPKERPTFETLRWKLEDYFETDSSYSDANNFIR"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P42685> <http://www.biopax.org/release/biopax-level3.owl#standardName> "Tyrosine-protein kinase FRK"^^<http://www.w3.org/2001/XMLSchema#string> .