. "SEQUENCE 198 AA; 21642 MW; 8229AA2733F77A10 CRC64;"^^ . "FUNCTION: Cell surface proteoglycan that bears heparan sulfate. SUBUNIT: Homodimer. Interacts (via its cytoplasmic domain) with GIPC (via its PDZ domain). Interacts (via its cytoplasmic domain) with NUDT16L1 (By similarity). Interacts with CDCP1 and SDCBP. SUBCELLULAR LOCATION: Membrane; Single-pass type I membrane protein. Secreted. Note=Shedding of the ectodomain produces a soluble form (By similarity). TISSUE SPECIFICITY: Expressed in epithelial and fibroblastic cells. PTM: Shedding is enhanced by a number of factors such as heparanase, thrombin or EGF. Also by stress and wound healing. PMA-mediated shedding is inhibited by TIMP3. SIMILARITY: Belongs to the syndecan proteoglycan family. GENE SYNONYMS:SDC4. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^ . . . . . . . . "SDC4_HUMAN"^^ . "SDC4"^^ . "Ryudocan core protein"^^ . "SYND4"^^ . "Amphiglycan"^^ . . . "MAPARLFALLLFFVGGVAESIRETEVIDPQDLLEGRYFSGALPDDEDVVGPGQESDDFELSGSGDLDDLEDSMIGPEVVHPLVPLDNHIPERAGSGSQVPTEPKKLEENEVIPKRISPVEESEDVSNKVSMSSTVQGSNIFERTEVLAALIVGGIVGILFAVFLILLLMYRMKKKDEGSYDLGKKPIYKKAPTNEFYA"^^ . "Syndecan-4"^^ .