<http://identifiers.org/uniprot/P24547> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#ProteinReference> .
<http://identifiers.org/uniprot/P24547> <http://www.biopax.org/release/biopax-level3.owl#comment> "FUNCTION: Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate- limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism (By similarity). It may also have a role in the development of malignancy and the growth progression of some tumors. CATALYTIC ACTIVITY: Inosine 5'-phosphate + NAD(+) + H(2)O = xanthosine 5'-phosphate + NADH. COFACTOR: Potassium (By similarity). ENZYME REGULATION: Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH (By similarity). PATHWAY: Purine metabolism; XMP biosynthesis via de novo pathway; XMP from IMP: step 1/1. SUBUNIT: Homotetramer. SUBCELLULAR LOCATION: Cytoplasm (By similarity). Nucleus (By similarity). SIMILARITY: Belongs to the IMPDH/GMPR family. SIMILARITY: Contains 2 CBS domains. GENE SYNONYMS:Impdh2. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P24547> <http://www.biopax.org/release/biopax-level3.owl#comment> "SEQUENCE 514 AA; 55815 MW; 17D25A5C5EBCC439 CRC64;"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P24547> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q91Z11> .
<http://identifiers.org/uniprot/P24547> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:NCBI+GENE_23918> .
<http://identifiers.org/uniprot/P24547> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:REFSEQ_NP_035960> .
<http://identifiers.org/uniprot/P24547> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:MOUSE+GENOME+DATABASE_MGI%3A109367> .
<http://identifiers.org/uniprot/P24547> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q61734> .
<http://identifiers.org/uniprot/P24547> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_P24547> .
<http://identifiers.org/uniprot/P24547> <http://www.biopax.org/release/biopax-level3.owl#displayName> "IMDH2_MOUSE"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P24547> <http://www.biopax.org/release/biopax-level3.owl#name> "1.1.1.205"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P24547> <http://www.biopax.org/release/biopax-level3.owl#name> "IMPDH-II"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P24547> <http://www.biopax.org/release/biopax-level3.owl#name> "IMPDH 2"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P24547> <http://www.biopax.org/release/biopax-level3.owl#name> "IMP dehydrogenase 2"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P24547> <http://www.biopax.org/release/biopax-level3.owl#name> "Impdh2"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P24547> <http://www.biopax.org/release/biopax-level3.owl#name> "IMPD 2"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P24547> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:IMDH2_MOUSE_4> .
<http://identifiers.org/uniprot/P24547> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:IMDH2_MOUSE_3> .
<http://identifiers.org/uniprot/P24547> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:IMDH2_MOUSE_2> .
<http://identifiers.org/uniprot/P24547> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:IMDH2_MOUSE_1> .
<http://identifiers.org/uniprot/P24547> <http://www.biopax.org/release/biopax-level3.owl#organism> <http://identifiers.org/taxonomy/10090> .
<http://identifiers.org/uniprot/P24547> <http://www.biopax.org/release/biopax-level3.owl#sequence> "MADYLISGGTSYVPDDGLTAQQLFNCGDGLTYNDFLILPGYIDFTADQVDLTSALTKKITLKTPLVSSPMDTVTEAGMAIAMALTGGIGFIHHNCTPEFQANEVRKVKKYEQGFITDPVVLSPKDRVRDVFEAKARHGFCGIPITDTGRMGSRLVGIISSRDIDFLKEEEHDRFLEEIMTKREDLVVAPAGVTLKEANEILQRSKKGKLPIVNENDELVAIIARTDLKKNRDYPLASKDAKKQLLCGAAIGTHEDDKYRLDLLALAGVDVVVLDSSQGNSIFQINMIKYIKEKYPSLQVIGGNVVTAAQAKNLIDAGVDALRVGMGSGSICITQEVLACGRPQATAVYKVSEYARRFGVPVIADGGIQNVGHIAKALALGASTVMMGSLLAATTEAPGEYFFSDGIRLKKYRGMGSLDAMDKHLSSQNRYFSEADKIKVAQGVSGAVQDKGSIHKFVPYLIAGIQHSCQDIGAKSLTQVRAMMYSGELKFEKRTSSAQVEGGVHSLHSYEKRLF"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P24547> <http://www.biopax.org/release/biopax-level3.owl#standardName> "Inosine-5'-monophosphate dehydrogenase 2"^^<http://www.w3.org/2001/XMLSchema#string> .