. "SEQUENCE 304 AA; 35015 MW; 5281E32B758B44FE CRC64;"^^ . "FUNCTION: Inhibits factor X (X(a)) directly and, in a Xa-dependent way, inhibits VIIa/tissue factor activity, presumably by forming a quaternary Xa/LACI/VIIa/TF complex. It possesses an antithrombotic action and also the ability to associate with lipoproteins in plasma. SUBCELLULAR LOCATION: Secreted. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=Alpha; Synonyms=TFPIalpha; IsoId=P10646-1; Sequence=Displayed; Name=Beta; Synonyms=TFPIbeta; IsoId=P10646-2; Sequence=VSP_003030, VSP_003031; TISSUE SPECIFICITY: Mostly in endothelial cells. DOMAIN: This inhibitor contains three inhibitory domains. The first domain interacts with VIIa and TF, the second one with Xa. PTM: O-glycosylated. SIMILARITY: Contains 3 BPTI/Kunitz inhibitor domains. WEB RESOURCE: Name=Wikipedia; Note=TFPI entry; URL=\"http://en.wikipedia.org/wiki/TFPI\"; WEB RESOURCE: Name=SeattleSNPs; URL=\"http://pga.gs.washington.edu/data/tfpi/\"; GENE SYNONYMS:TFPI LACI TFPI1. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^ . . . . . . . . "TFPI1_HUMAN"^^ . "TFPI"^^ . "Lipoprotein-associated coagulation inhibitor"^^ . "EPI"^^ . "Extrinsic pathway inhibitor"^^ . "LACI"^^ . . "MIYTMKKVHALWASVCLLLNLAPAPLNADSEEDEEHTIITDTELPPLKLMHSFCAFKADDGPCKAIMKRFFFNIFTRQCEEFIYGGCEGNQNRFESLEECKKMCTRDNANRIIKTTLQQEKPDFCFLEEDPGICRGYITRYFYNNQTKQCERFKYGGCLGNMNNFETLEECKNICEDGPNGFQVDNYGTQLNAVNNSLTPQSTKVPSLFEFHGPSWCLTPADRGLCRANENRFYYNSVIGKCRPFKYSGCGGNENNFTSKQECLRACKKGFIQRISKGGLIKTKRKRKKQRVKIAYEEIFVKNM"^^ . "Tissue factor pathway inhibitor"^^ .