. "FUNCTION: Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. FUNCTION: Acts as a cytokine involved in enhancing production of interferon-gamma and interleukin-12 and reducing production of interleukin-10 and is essential in the pathway that leads to type I immunity (By similarity). SUBUNIT: Ligand for integrin alpha-V/beta-3. SUBCELLULAR LOCATION: Secreted. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=5; Name=A; Synonyms=OPN-a, OP1B; IsoId=P10451-1; Sequence=Displayed; Name=B; Synonyms=OPN-b, OP1A; IsoId=P10451-2; Sequence=VSP_003778; Name=C; Synonyms=OPN-c; IsoId=P10451-3; Sequence=VSP_003777; Name=D; IsoId=P10451-4; Sequence=VSP_011639; Name=5; IsoId=P10451-5; Sequence=VSP_043695; Note=No experimental confirmation available; TISSUE SPECIFICITY: Bone. Found in plasma. PTM: Extensively phosphorylated by FAM20C in the extracelllular medium at multiple sites within the S-x-E/pS motif. PTM: N- and O-glycosylated. SIMILARITY: Belongs to the osteopontin family. WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL=\"http://atlasgeneticsoncology.org/Genes/SPP1ID42379ch4q22.html\"; WEB RESOURCE: Name=Wikipedia; Note=Osteopontin entry; URL=\"http://en.wikipedia.org/wiki/Osteopontin\"; GENE SYNONYMS:SPP1 BNSP OPN. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^ . "SEQUENCE 314 AA; 35423 MW; 4996429EC4752B86 CRC64;"^^ . . . . . . . . . . . . . . "OSTP_HUMAN"^^ . "Secreted phosphoprotein 1"^^ . "SPP-1"^^ . "Uropontin"^^ . "Nephropontin"^^ . "Bone sialoprotein 1"^^ . "Urinary stone protein"^^ . "SPP1"^^ . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . "MRIAVICFCLLGITCAIPVKQADSGSSEEKQLYNKYPDAVATWLNPDPSQKQNLLAPQNAVSSEETNDFKQETLPSKSNESHDHMDDMDDEDDDDHVDSQDSIDSNDSDDVDDTDDSHQSDESHHSDESDELVTDFPTDLPATEVFTPVVPTVDTYDGRGDSVVYGLRSKSKKFRRPDIQYPDATDEDITSHMESEELNGAYKAIPVAQDLNAPSDWDSRGKDSYETSQLDDQSAETHSHKQSRLYKRKANDESNEHSDVIDSQELSKVSREFHSHEFHSHEDMLVVDPKSKEEDKHLKFRISHELDSASSEVN"^^ . "Osteopontin"^^ .