<http://identifiers.org/uniprot/O35182> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#ProteinReference> .
<http://identifiers.org/uniprot/O35182> <http://www.biopax.org/release/biopax-level3.owl#comment> "FUNCTION: Binds to regulatory elements in target promoter regions (By similarity). Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Inhibits phosphorylation activity of SMAD1 induced by BMP type IB receptor and interferes with the phosphorylation of SMAD2 and the subsequent heteromerization with SMAD4. SUBUNIT: Interacts with STAMBP and PRKX (By similarity). Interacts with RNF111 and AXIN1. Interacts with TGF-beta type I receptor superfamily members. Interacts with NEDD4L. Interacts with WWP1. SUBCELLULAR LOCATION: Nucleus (By similarity). TISSUE SPECIFICITY: Ubiquitous in various organs, with higher levels in lung. PTM: Ubiquitinated by WWP1. SIMILARITY: Belongs to the dwarfin/SMAD family. SIMILARITY: Contains 1 MH1 (MAD homology 1) domain. SIMILARITY: Contains 1 MH2 (MAD homology 2) domain. GENE SYNONYMS:Smad6 Madh6 Madh7 Msmad6. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O35182> <http://www.biopax.org/release/biopax-level3.owl#comment> "SEQUENCE 495 AA; 53714 MW; D9282D42B120C507 CRC64;"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O35182> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:MOUSE+GENOME+DATABASE_MGI%3A1336883> .
<http://identifiers.org/uniprot/O35182> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q9CW62> .
<http://identifiers.org/uniprot/O35182> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:REFSEQ_NP_032568> .
<http://identifiers.org/uniprot/O35182> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_O35182> .
<http://identifiers.org/uniprot/O35182> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:NCBI+GENE_17130> .
<http://identifiers.org/uniprot/O35182> <http://www.biopax.org/release/biopax-level3.owl#displayName> "SMAD6_MOUSE"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O35182> <http://www.biopax.org/release/biopax-level3.owl#name> "Smad6"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O35182> <http://www.biopax.org/release/biopax-level3.owl#name> "Mothers against DPP homolog 6"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O35182> <http://www.biopax.org/release/biopax-level3.owl#name> "MAD homolog 6"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O35182> <http://www.biopax.org/release/biopax-level3.owl#name> "SMAD 6"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O35182> <http://www.biopax.org/release/biopax-level3.owl#name> "SMAD family member 6"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O35182> <http://www.biopax.org/release/biopax-level3.owl#name> "Mad homolog 7"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O35182> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:SMAD6_MOUSE_1> .
<http://identifiers.org/uniprot/O35182> <http://www.biopax.org/release/biopax-level3.owl#organism> <http://identifiers.org/taxonomy/10090> .
<http://identifiers.org/uniprot/O35182> <http://www.biopax.org/release/biopax-level3.owl#sequence> "MFRSKRSGLVRRLWRSRVVPDREEGSGGGGGVDEDGSLGSRAEPAPRAREGGGCSRSEVRSVAPRRPRDAVGPRGAAIAGRRRRTGGLPRPVSESGAGAGGSPLDVAEPGGPGWLPESDCETVTCCLFSERDAAGAPRDSGDPQARQSPEPEEGGGPRSREARSRLLLLEQELKTVTYSLLKRLKERSLDTLLEAVESRGGVPGGCVLVPRADLRLGGQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFTAAADGPTVCCNPYHFSRLCGPESPPPPYSRLSPPDQYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLLQHADAAHGPYDPHSVRISFAKGWGPCYSRQFITSCPCWLEILLNNHR"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O35182> <http://www.biopax.org/release/biopax-level3.owl#standardName> "Mothers against decapentaplegic homolog 6"^^<http://www.w3.org/2001/XMLSchema#string> .