<http://identifiers.org/uniprot/O15372> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#ProteinReference> .
<http://identifiers.org/uniprot/O15372> <http://www.biopax.org/release/biopax-level3.owl#comment> "FUNCTION: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S preinitiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of posttermination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. SUBUNIT: Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination- dependent manner. SUBCELLULAR LOCATION: Cytoplasm (Probable). MASS SPECTROMETRY: Mass=40010.4; Method=Unknown; Range=1-352; Source=PubMed:17322308; MASS SPECTROMETRY: Mass=39842.6; Mass_error=0.4; Method=MALDI; Range=1-352; Source=PubMed:18599441; SIMILARITY: Belongs to the eIF-3 subunit H family. SIMILARITY: Contains 1 MPN (JAB/Mov34) domain. GENE SYNONYMS:EIF3H EIF3S3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O15372> <http://www.biopax.org/release/biopax-level3.owl#comment> "SEQUENCE 352 AA; 39930 MW; F3A6EFA0CEF587D0 CRC64;"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O15372> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:NCBI+GENE_8667> .
<http://identifiers.org/uniprot/O15372> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:HGNC_HGNC%3A3273> .
<http://identifiers.org/uniprot/O15372> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_O15372> .
<http://identifiers.org/uniprot/O15372> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:REFSEQ_NP_003747> .
<http://identifiers.org/uniprot/O15372> <http://www.biopax.org/release/biopax-level3.owl#displayName> "EIF3H_HUMAN"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O15372> <http://www.biopax.org/release/biopax-level3.owl#name> "eIF3 p40 subunit"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O15372> <http://www.biopax.org/release/biopax-level3.owl#name> "Eukaryotic translation initiation factor 3 subunit 3"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O15372> <http://www.biopax.org/release/biopax-level3.owl#name> "EIF3H"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O15372> <http://www.biopax.org/release/biopax-level3.owl#name> "eIF3h"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O15372> <http://www.biopax.org/release/biopax-level3.owl#name> "eIF-3-gamma"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O15372> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:EIF3H_HUMAN_2> .
<http://identifiers.org/uniprot/O15372> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:EIF3H_HUMAN_1> .
<http://identifiers.org/uniprot/O15372> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:EIF3H_HUMAN_4> .
<http://identifiers.org/uniprot/O15372> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:EIF3H_HUMAN_3> .
<http://identifiers.org/uniprot/O15372> <http://www.biopax.org/release/biopax-level3.owl#organism> <http://identifiers.org/taxonomy/9606> .
<http://identifiers.org/uniprot/O15372> <http://www.biopax.org/release/biopax-level3.owl#sequence> "MASRKEGTGSTATSSSSTAGAAGKGKGKGGSGDSAVKQVQIDGLVVLKIIKHYQEEGQGTEVVQGVLLGLVVEDRLEITNCFPFPQHTEDDADFDEVQYQMEMMRSLRHVNIDHLHVGWYQSTYYGSFVTRALLDSQFSYQHAIEESVVLIYDPIKTAQGSLSLKAYRLTPKLMEVCKEKDFSPEALKKANITFEYMFEEVPIVIKNSHLINVLMWELEKKSAVADKHELLSLASSNHLGKNLQLLMDRVDEMSQDIVKYNTYMRNTSKQQQQKHQYQQRRQQENMQRQSRGEPPLPEEDLSKLFKPPQPPARMDSLLIAGQINTYCQNIKEFTAQNLGKLFMAQALQEYNN"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O15372> <http://www.biopax.org/release/biopax-level3.owl#standardName> "Eukaryotic translation initiation factor 3 subunit H"^^<http://www.w3.org/2001/XMLSchema#string> .