. "FUNCTION: Catalyzes the covalent attachment of ubiquitin or ISG15 to other proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Promotes ubiquitination and subsequent proteasomal degradation of FLT3. CATALYTIC ACTIVITY: ATP + ubiquitin + protein lysine = AMP + diphosphate + protein N-ubiquityllysine. PATHWAY: Protein modification; protein ubiquitination. SUBUNIT: Interacts with RNF19A, RNF19B and RNF144B. Interacts with FLT3 (tyrosine phosphorylated). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O14933-1; Sequence=Displayed; Name=2; IsoId=O14933-2; Sequence=VSP_037344; TISSUE SPECIFICITY: Present in natural killer cells (at protein level). INDUCTION: By IFNB1/IFN-beta. PTM: ISGylated. SIMILARITY: Belongs to the ubiquitin-conjugating enzyme family. SEQUENCE CAUTION: Sequence=CAB64566.1; Type=Erroneous initiation; GENE SYNONYMS:UBE2L6 UBCH8. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^ . "SEQUENCE 153 AA; 17769 MW; D79768775344EFAE CRC64;"^^ . . . . . . . . . . "UB2L6_HUMAN"^^ . "6.3.2.19"^^ . "UbcH8"^^ . "RIG-B"^^ . "Retinoic acid-induced gene B protein"^^ . "Ubiquitin carrier protein L6"^^ . "Ubiquitin-protein ligase L6"^^ . "UBE2L6"^^ . . "MMASMRVVKELEDLQKKPPPYLRNLSSDDANVLVWHALLLPDQPPYHLKAFNLRISFPPEYPFKPPMIKFTTKIYHPNVDENGQICLPIISSENWKPCTKTCQVLEALNVLVNRPNIREPLRMDLADLLTQNPELFRKNAEEFTLRFGVDRPS"^^ . "Ubiquitin/ISG15-conjugating enzyme E2 L6"^^ .