<http://identifiers.org/uniprot/O00401> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#ProteinReference> .
<http://identifiers.org/uniprot/O00401> <http://www.biopax.org/release/biopax-level3.owl#comment> "SEQUENCE 505 AA; 54827 MW; B5895C6055E23049 CRC64;"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O00401> <http://www.biopax.org/release/biopax-level3.owl#comment> "FUNCTION: Regulates actin polymerization by stimulating the actin- nucleating activity of the Arp2/3 complex. Binds to HSF1/HSTF1 and forms a complex on heat shock promoter elements (HSE) that negatively regulates HSP90 expression. SUBUNIT: Binds actin and the Arp2/3 complex. Interacts with CDC42. Binds to SH3 domains of GRB2. Interacts with the C-terminal SH3 domain of DNMBP. Interacts with SNX9. Interacts with the WW domains of PRPF40A/FBP11. Interacts with PTK2/FAK1 (By similarity). Interacts with NOSTRIN. Interacts with Shigella flexneri protein IcsA. The interaction with IcsA enhances the affinity of WASL for Arp2/3, thus assembling a tight complex which has maximal activity in actin assembly. Interacts with E.coli effector protein EspF(U). Identified in a complex containing at least WASL, BAIAP2L1 and E.coli EspF(U). Binds to TNK2. SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton (By similarity). Nucleus (By similarity). Note=Preferentially localized in the cytoplasm when phosphorylated and in the nucleus when unphosphorylated (By similarity). PTM: Phosphorylation at Ser-242, Tyr-256, Ser-484 and Ser-485 enhances actin polymerization activity. SIMILARITY: Contains 1 CRIB domain. SIMILARITY: Contains 1 WH1 domain. SIMILARITY: Contains 2 WH2 domains. GENE SYNONYMS:WASL. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O00401> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_O00401> .
<http://identifiers.org/uniprot/O00401> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:NCBI+GENE_8976> .
<http://identifiers.org/uniprot/O00401> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:REFSEQ_NP_003932> .
<http://identifiers.org/uniprot/O00401> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q7Z746> .
<http://identifiers.org/uniprot/O00401> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:HGNC_HGNC%3A12735> .
<http://identifiers.org/uniprot/O00401> <http://www.biopax.org/release/biopax-level3.owl#displayName> "WASL_HUMAN"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O00401> <http://www.biopax.org/release/biopax-level3.owl#name> "N-WASP"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O00401> <http://www.biopax.org/release/biopax-level3.owl#name> "WASL"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O00401> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:WASL_HUMAN_3> .
<http://identifiers.org/uniprot/O00401> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:WASL_HUMAN_4> .
<http://identifiers.org/uniprot/O00401> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:WASL_HUMAN_1> .
<http://identifiers.org/uniprot/O00401> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:WASL_HUMAN_2> .
<http://identifiers.org/uniprot/O00401> <http://www.biopax.org/release/biopax-level3.owl#organism> <http://identifiers.org/taxonomy/9606> .
<http://identifiers.org/uniprot/O00401> <http://www.biopax.org/release/biopax-level3.owl#sequence> "MSSVQQQPPPPRRVTNVGSLLLTPQENESLFTFLGKKCVTMSSAVVQLYAADRNCMWSKKCSGVACLVKDNPQRSYFLRIFDIKDGKLLWEQELYNNFVYNSPRGYFHTFAGDTCQVALNFANEEEAKKFRKAVTDLLGRRQRKSEKRRDPPNGPNLPMATVDIKNPEITTNRFYGPQVNNISHTKEKKKGKAKKKRLTKADIGTPSNFQHIGHVGWDPNTGFDLNNLDPELKNLFDMCGISEAQLKDRETSKVIYDFIEKTGGVEAVKNELRRQAPPPPPPSRGGPPPPPPPPHNSGPPPPPARGRGAPPPPPSRAPTAAPPPPPPSRPSVAVPPPPPNRMYPPPPPALPSSAPSGPPPPPPSVLGVGPVAPPPPPPPPPPPGPPPPPGLPSDGDHQVPTTAGNKAALLDQIREGAQLKKVEQNSRPVSCSGRDALLDQIRQGIQLKSVADGQESTPPTPAPTSGIVGALMEVMQKRSKAIHSSDEDEDEDDEEDFEDDDEWED"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O00401> <http://www.biopax.org/release/biopax-level3.owl#standardName> "Neural Wiskott-Aldrich syndrome protein"^^<http://www.w3.org/2001/XMLSchema#string> .