. . "CYP11B2 encodes a member of the cytochrome P450 superfamily of heme containing membrane associated enzymes. These proteins function as monooxygenases utilizing NADPH for the reduction of molecular oxygen via a membrane bound electron transfer system. CYP11B2 localizes to the mitochondrial inner membrane and catalyzes the conversion of 11-deoxycortisone to aldosterone in three distinct reactions at a single active site. |CITS: [1741400]|. In these reactions the electrons from NADPH are transferred to a flavin containing protein, ferredoxin reductase and subsequently to ferredoxin (a non-heme iron-sulfur protein), to CYP11B2 and finally to activate the oxygen substrate |CITS: [9029726]|. The enzyme has steroid 18-hydroxylase activity to synthesize aldosterone and 18-oxocortisol as well as steroid 11 beta-hydroxylase activity. Mutations in this gene cause corticosterone methyl oxidase deficiency."^^ . . . . . . . . . . . . . . . . . . . . . . . . . . "ALDOS"^^ . "P-450C18"^^ . "P-450Aldo"^^ . "CYPXIB2"^^ . "Aldosterone synthase"^^ . "cytochrome P450 11B, mitochondrial"^^ . "Aldosterone-synthesizing enzyme"^^ . "Steroid 18-hydroxylase"^^ . . "cyp11B2"^^ .