. "ACTIVATION"^^ . . "The kinetic constants are for the enzyme purified directly from human brain. Sulfation proceeds in an ordered, bisubstrate reaction mechanism with PAPS as the leading substrate |CITS: [3860259]|. The enzyme has been reported to undergo substrate inhibition by dopamine |CITS: [14871892]|. The enzyme also has a unique D-dopa/D-tyrosine-sulfating activity stimulated by Mn²⁺ |CITS: [12424257]|."^^ . . . . . "dopamine sulfotransferase"^^ . . "dopamine sulfotransferase"^^ .