. "Reviewed: D'Eustachio, P, 2008-05-28 08:30:54"^^ . "Edited: Jassal, B, 2008-05-19 12:57:01"^^ . "Authored: Jassal, B, 2008-05-19 12:57:01"^^ . "CYP3A43 belongs to the CYP3A family, of which CYP3A4 is the most active member in the biotransformation of xenobiotics. Testosterone metabolites are a major determinant of prostate growth and differentiation. CYP3A43, which is expressed in the prostate, exhibits minor 6-beta-hydroxylation activity towards testosterone. Thus, CYP3A43 may be involved in the etiology of prostate cancer."^^ . . . . . . . "CYP3A43 catalyzes the 6beta-hydroxylation of testosterone"^^ . . . . . . . . . . .