. "Authored: Nasi, S, Annibali, D, 2006-10-10 09:07:07"^^ . "Edited: Jassal, B, 2008-05-20 12:26:36"^^ . "Reviewed: Friedman, WJ, 2008-05-20 12:23:46"^^ . "Reviewed: Chao, MV, 2008-05-28 09:46:01"^^ . "Atypical PKC isoforms phosphorylate the beta subunit of the IKK complex (on Serines 177 and 181) thereby serving as an IKK kinase. TRAF6 and p62 as well appear to have a role in IKK activation. TRAF6 mediates the assembly of K63-linked poly-Ub chains required for IKK activation. The ubiquitin binding property of p62 may also be relevant in regulating IKK activation."^^ . . . . . . "IKKbeta is activated"^^ . "2.7.11"^^ . . . . . . . . . .