. "Authored: Garapati, P V, 2011-01-18"^^ . "Edited: Garapati, P V, 2011-01-18"^^ . "Reviewed: Zhang, DE, 2011--0-2-"^^ . "Ubiquitin conjugating E2 enzymes UBC13 and UBCH6 are targets for ISGylation. This suppresses the ubiquitin-conjugating activity of both UBC13 and UBCH6. This modification may play an important role in the control of signal transduction pathways, such as the NF-kB pathway, which are associated with K63-linked polyubiquitination (Takeuchi et al, 2005)."^^ . . . . . . . . . "ISGylation of E2 conjugating enzymes"^^ . "6.3.2.19"^^ . . . . . . . . . . . .