. "Authored: Garapati, P V, 2011-01-18"^^ . "Edited: Garapati, P V, 2011-01-18"^^ . "Reviewed: Zhang, DE, 2011--0-2-"^^ . "Protein phosphatase 1 beta (PPM1B/PP2CB) is a target for ISG15. PP2CB dephosphorylates TAK1 and suppresses TAK1/TAB1-mediated IkB alpha degradation and thereby controls the NF-kB signaling pathway, which plays a critical role in innate and adaptive immunity and cancer. ISGylation of PP2CB may block the suppressive function of the phosphatase against TAK1/TAB1 mediated NF-kB activation."^^ . . . . . . . . . "ISGylation of protein phosphatase 1 beta (PP2CB)"^^ . "6.3.2.19"^^ . . . . . . . . . . . .