<http://www.reactome.org/biopax/48887BiochemicalReaction2270> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#BiochemicalReaction> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2270> <http://www.biopax.org/release/biopax-level3.owl#comment> "Authored: Rudd, C.E., de Bono, B, Garapati, P V, 2008-01-24 15:53:10"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2270> <http://www.biopax.org/release/biopax-level3.owl#comment> "Reviewed: Trowsdale, J, 2008-02-26 12:02:59"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2270> <http://www.biopax.org/release/biopax-level3.owl#comment> "ITK is a member of the Tec protein tyrosine kinase family which forms a complex with SLP-76 after TCR activation. ITK has N-terminal pleckstrin homology (PH) domain, a Tec homology (TH) domain, a proline rich domain, a SH3 domain, an SH2 domain and a C-term kinase domain. The SH2 domain of ITK may interact with Y145 within the N-ter acidic domain of SLP-76 and the SH3 domain of the ITK binds the proline rich region of SLP-76. ITK plays an important role in phosphorylating and activating PLC-gamma-1, leading to the development of second-messenger molecules."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2270> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME+DATABASE+ID_202375> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2270> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:REACTOME_REACT_12604_1> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2270> <http://www.biopax.org/release/biopax-level3.owl#xref> <http://identifiers.org/pubmed/17652306> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2270> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <urn:biopax:Provenance:reactome_hm_41> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2270> <http://www.biopax.org/release/biopax-level3.owl#dataSource> <http://www.reactome.org/biopax/48887Provenance1> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2270> <http://www.biopax.org/release/biopax-level3.owl#displayName> "Recruitment of ITK to SLP-76"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2270> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887Protein8198> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2270> <http://www.biopax.org/release/biopax-level3.owl#left> <http://www.reactome.org/biopax/48887Complex2757> .
<http://www.reactome.org/biopax/48887BiochemicalReaction2270> <http://www.biopax.org/release/biopax-level3.owl#right> <http://www.reactome.org/biopax/48887Complex2758> .
<http://www.reactome.org/biopax/48887PathwayStep2933> <http://www.biopax.org/release/biopax-level3.owl#stepProcess> <http://www.reactome.org/biopax/48887BiochemicalReaction2270> .
<http://www.reactome.org/biopax/48887Pathway612> <http://www.biopax.org/release/biopax-level3.owl#pathwayComponent> <http://www.reactome.org/biopax/48887BiochemicalReaction2270> .