. "Authored: Matthews, L, 2008-12-01 04:46:41"^^ . "Edited: Matthews, L, 2009-02-21 05:37:28"^^ . "Reviewed: Cowan, NJ, 2009-01-21 16:47:24"^^ . "Group II chaperonins enclose substrate proteins following substrate binding through the formation of a \"built- in\" lid over the central cavity. Upon ATP binding, lid formation is triggered by the transition state of ATP hydrolysis (Meyer, et al., 2003). In the case of CCT-mediated tubulin folding, one or more rounds of ATP hydrolysis are likely required before the association of non-exchangeable GTP with chaperonin-bound alpha tubulin."^^ . . . . . . "Hydrolysis of ATP and release of tubulin folding intermediate from CCT/TriC"^^ . . . . . . . . .