. "Reviewed: Simon, V, 2007-01-30 23:07:12"^^ . "Reviewed: Mulder, L, 2007-01-30 22:57:00"^^ . "Edited: Matthews, L, 2007-01-30 11:27:41"^^ . "Authored: Matthews, L, 2006-06-07 20:09:24"^^ . "During reverse transcription, APOBEC3G-mediated minus-strand deamination occurs within a CC dinucleotide context over the entire length of the HIV-1 genome (Yu et al., 2004).
The polypurine tract is essential for plus strand synthesis and is located at the 3\u00C3\u00A2\u00E2?\u00AC\u00E2?\u00A2 end of the retroviral genome. HIV-1 encodes an additional central polypurine tract located in the middle of the genome which also serves as primer for plus strand synthesis.
Deamination of the minus strand continues throughout its synthesis with the frequency of deamination events increasing from the 5\u00C3\u00A2\u00E2?\u00AC\u00E2?\u00A2 to 3\u00C3\u00A2\u00E2?\u00AC\u00E2?\u00A2 regions. A 400bp region downstream of the central polypurine tract seems to be protected from deamination (Wurtzer et al., 2006)"^^ . . . . . . . . "Deamination of C residues during synthesis of HIV-1 reverse transcript minus-strand"^^ . "3.5.4.13"^^ . . . . . . . .