. "Missense mutations, three of them novel (Gly47-->Cys, Arg178-->Pro, Ala259-->Thr), were found in the protein C genes of four patients with inherited protein C deficiency associated with venous thrombosis. Comparison with the phenotypic effects of mutations in the analogous residues of factor IX and the use of a molecular model of protein C provided explanations as to how these lesions might alter either the structure, function or stability of the protein C molecules encoded." . . . "Blood Coagul. Fibrinolysis" . "Chisholm M." . "Kakkar V.V." . "Cooper D.N." . "Chitolie A." . "Bevan D." . "Millar D.S." . "Reynaud J." . "1995"^^ . "138-140" . "Three novel mutations in the protein C (PROC) gene causing venous thrombosis." . "6" . . . .