. "The mechanism controlling the development of dopaminergic (DA) and serotonergic (5HT) neurons in vertebrates is not well understood. Here we characterized a zebrafish mutant--too few (tof)--that develops hindbrain 5HT and noradrenergic neurons, but does not develop hypothalamic DA and 5HT neurons. tof encodes a forebrain-specific zinc finger transcription repressor that is homologous to the mammalian Fezl (forebrain embryonic zinc finger-like protein). Mosaic and co-staining analyses showed that fezl was not expressed in DA or 5HT neurons and instead controlled development of these neurons non-cell-autonomously. Both the eh1-related repressor motif and the second zinc finger domain were necessary for tof function. Our results indicate that tof/fezl is a key component in regulating the development of monoaminergic neurons in the vertebrate brain." . . . "Nat. Neurosci." . "Rosenthal A." . "Hibi M." . "Hashimoto H." . "Talbot W.S." . "Levkowitz G." . "Schilbach S." . "Zeller J." . "Sirotkin H.I." . "French D." . "2003"^^ . "28-33" . "Zinc finger protein too few controls the development of monoaminergic neurons." . "6" . "doi:10.1038/nn979" . . . . . .