. "\"Catalysis of the reaction: a 3-beta-hydroxy-delta(5)-steroid + NAD+ = a 3-oxo-delta(5)-steroid + NADH + H(+).\" [EC:1.1.1.145]" . . "3-beta-hydroxy-delta5-steroid dehydrogenase activity" . "3-beta-hydroxy-5-ene steroid dehydrogenase activity" . "3-beta-hydroxy-D5-steroid dehydrogenase activity" . "3beta-hydroxy steroid dehydrogenase/isomerase activity" . "3beta-hydroxy-5-ene steroid dehydrogenase activity" . "3beta-hydroxy-5-ene-steroid dehydrogenase activity" . "3beta-hydroxy-5-ene-steroid oxidoreductase activity" . "3beta-hydroxy-delta5-C27-steroid dehydrogenase/isomerase activity" . "3beta-hydroxy-delta5-steroid dehydrogenase activity" . "3beta-hydroxy-delta5-steroid:NAD+ 3-oxidoreductase activity" . "5-ene-3-beta-hydroxysteroid dehydrogenase activity" . "delta5-3beta-hydroxysteroid dehydrogenase activity" . "steroid-delta5-3beta-ol dehydrogenase activity" . "EC:1.1.1.145" . "MetaCyc:1.1.1.145-RXN" . "Reactome:REACT_10031 \"17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Homo sapiens\"" . "Reactome:REACT_10067 \"7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Homo sapiens\"" . "Reactome:REACT_100839 \"Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Danio rerio\"" . "Reactome:REACT_10090 \"Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Homo sapiens\"" . "Reactome:REACT_10115 \"Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Homo sapiens\"" . "Reactome:REACT_101983 \"17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Bos taurus\"" . "Reactome:REACT_103390 \"Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Bos taurus\"" . "Reactome:REACT_103657 \"Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Sus scrofa\"" . "Reactome:REACT_103990 \"Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Danio rerio\"" . "Reactome:REACT_104422 \"Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Drosophila melanogaster\"" . "Reactome:REACT_104615 \"Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Gallus gallus\"" . "Reactome:REACT_105565 \"Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Mus musculus\"" . "Reactome:REACT_106120 \"Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Bos taurus\"" . "Reactome:REACT_106214 \"7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Danio rerio\"" . "Reactome:REACT_106644 \"7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Taeniopygia guttata\"" . "Reactome:REACT_108035 \"7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Canis familiaris\"" . "Reactome:REACT_108087 \"7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Xenopus tropicalis\"" . "Reactome:REACT_108432 \"17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Xenopus tropicalis\"" . "Reactome:REACT_109510 \"Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Mus musculus\"" . "Reactome:REACT_111989 \"17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Mycobacterium tuberculosis\"" . "Reactome:REACT_112248 \"Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Escherichia coli\"" . "Reactome:REACT_113096 \"Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Mycobacterium tuberculosis\"" . "Reactome:REACT_113257 \"Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Escherichia coli\"" . "Reactome:REACT_113772 \"Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Escherichia coli\"" . "Reactome:REACT_114424 \"17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Escherichia coli\"" . "Reactome:REACT_114777 \"7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Mycobacterium tuberculosis\"" . "Reactome:REACT_114921 \"Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Mycobacterium tuberculosis\"" . "Reactome:REACT_115275 \"7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Escherichia coli\"" . "Reactome:REACT_115303 \"Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Mycobacterium tuberculosis\"" . "Reactome:REACT_28427 \"Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Danio rerio\"" . "Reactome:REACT_28467 \"Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Drosophila melanogaster\"" . "Reactome:REACT_29450 \"17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Danio rerio\"" . "Reactome:REACT_30525 \"Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Taeniopygia guttata\"" . "Reactome:REACT_30795 \"Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Rattus norvegicus\"" . "Reactome:REACT_30899 \"Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Canis familiaris\"" . "Reactome:REACT_32283 \"Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Gallus gallus\"" . "Reactome:REACT_32783 \"7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Mus musculus\"" . "Reactome:REACT_32924 \"17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Gallus gallus\"" . "Reactome:REACT_33199 \"7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Sus scrofa\"" . "Reactome:REACT_33352 \"7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Gallus gallus\"" . "Reactome:REACT_34556 \"Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Rattus norvegicus\"" . "Reactome:REACT_77900 \"Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Drosophila melanogaster\"" . "Reactome:REACT_78893 \"Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Xenopus tropicalis\"" . "Reactome:REACT_79104 \"17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Sus scrofa\"" . "Reactome:REACT_79525 \"Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Rattus norvegicus\"" . "Reactome:REACT_79553 \"Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Bos taurus\"" . "Reactome:REACT_80359 \"7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Drosophila melanogaster\"" . "Reactome:REACT_80746 \"17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Rattus norvegicus\"" . "Reactome:REACT_81646 \"Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Taeniopygia guttata\"" . "Reactome:REACT_82293 \"Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Sus scrofa\"" . "Reactome:REACT_82688 \"17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Mus musculus\"" . "Reactome:REACT_84251 \"17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Canis familiaris\"" . "Reactome:REACT_85738 \"Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Canis familiaris\"" . "Reactome:REACT_86717 \"17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Drosophila melanogaster\"" . "Reactome:REACT_87612 \"17-Hydroxypregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione-17-ol, Taeniopygia guttata\"" . "Reactome:REACT_88118 \"Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Mus musculus\"" . "Reactome:REACT_88292 \"7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Rattus norvegicus\"" . "Reactome:REACT_88643 \"Cholest-5-ene-3beta,7alpha,24(S)-triol is oxidized and isomerized to 4-cholesten-7alpha,24(S)-diol-3-one, Xenopus tropicalis\"" . "Reactome:REACT_91120 \"Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Gallus gallus\"" . "Reactome:REACT_93787 \"Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Taeniopygia guttata\"" . "Reactome:REACT_94450 \"Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Xenopus tropicalis\"" . "Reactome:REACT_96507 \"Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Sus scrofa\"" . "Reactome:REACT_99573 \"Cholest-5-ene-3beta,7alpha,27-triol is oxidized and isomerized to 4-cholesten-7alpha,27-diol-3-one, Canis familiaris\"" . "Reactome:REACT_99689 \"7alpha-hydroxycholesterol is oxidized and isomerized to 4-cholesten-7alpha-ol-3-one, Bos taurus\"" . "Reactome:REACT_9989 \"Pregnenolone is dehydrogenated to form pregn-5-ene-3,20-dione, Homo sapiens\"" . . "3beta-HSDH" . "3beta-hydroxy-delta5-C27-steroid oxidoreductase" . "progesterone reductase activity" . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .