<http://identifiers.org/uniprot/Q9NR96> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#ProteinReference> .
<http://identifiers.org/uniprot/Q9NR96> <http://www.biopax.org/release/biopax-level3.owl#comment> "FUNCTION: Key component of innate and adaptive immunity. TLRs (Toll-like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine-phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Controls lymphocyte response to Helicobacter infection. SUBUNIT: Interacts with MYD88 via their respective TIR domains (By similarity). Interacts (via transmembrane domain) with UNC93B1 (By similarity). Interacts with CD300LH; the interaction may promote full activation of TLR9-triggered innate responses (By similarity). Interacts with BTK. Interacts with CNPY3 and HSP90B1; this interaction is required for proper folding in the endoplasmic reticulum. SUBCELLULAR LOCATION: Endoplasmic reticulum membrane; Single-pass type I membrane protein (By similarity). Endosome (By similarity). Lysosome (By similarity). Cytoplasmic vesicle, phagosome (By similarity). Note=Relocalizes from endoplasmic reticulum to endosome and lysosome upon stimulation with agonist (By similarity). ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=5; Comment=Additional isoforms seem to exist; Name=1; Synonyms=A; IsoId=Q9NR96-1; Sequence=Displayed; Name=2; Synonyms=B; IsoId=Q9NR96-2; Sequence=VSP_006520; Name=3; IsoId=Q9NR96-3; Sequence=VSP_006521; Name=4; IsoId=Q9NR96-4; Sequence=VSP_006522; Name=5; IsoId=Q9NR96-5; Sequence=VSP_006523; TISSUE SPECIFICITY: Highly expressed in spleen, lymph node, tonsil and peripheral blood leukocytes, especially in plasmacytoid pre- dendritic cells. Levels are much lower in monocytes and CD11c+ immature dendritic cells. Also detected in lung and liver. SIMILARITY: Belongs to the Toll-like receptor family. SIMILARITY: Contains 26 LRR (leucine-rich) repeats. SIMILARITY: Contains 1 TIR domain. GENE SYNONYMS:TLR9. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q9NR96> <http://www.biopax.org/release/biopax-level3.owl#comment> "SEQUENCE 1032 AA; 115860 MW; 71280AA9680EDCE2 CRC64;"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q9NR96> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:NCBI+GENE_54106> .
<http://identifiers.org/uniprot/Q9NR96> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q9HD68> .
<http://identifiers.org/uniprot/Q9NR96> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:REFSEQ_NP_059138> .
<http://identifiers.org/uniprot/Q9NR96> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q9HD69> .
<http://identifiers.org/uniprot/Q9NR96> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q9HD70> .
<http://identifiers.org/uniprot/Q9NR96> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q9NYC3> .
<http://identifiers.org/uniprot/Q9NR96> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:HGNC_HGNC%3A15633> .
<http://identifiers.org/uniprot/Q9NR96> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q6UVZ2> .
<http://identifiers.org/uniprot/Q9NR96> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q9NYC2> .
<http://identifiers.org/uniprot/Q9NR96> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q9NR96> .
<http://identifiers.org/uniprot/Q9NR96> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_B3Y661> .
<http://identifiers.org/uniprot/Q9NR96> <http://www.biopax.org/release/biopax-level3.owl#displayName> "TLR9_HUMAN"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q9NR96> <http://www.biopax.org/release/biopax-level3.owl#name> "CD289"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q9NR96> <http://www.biopax.org/release/biopax-level3.owl#name> "TLR9"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q9NR96> <http://www.biopax.org/release/biopax-level3.owl#organism> <http://identifiers.org/taxonomy/9606> .
<http://identifiers.org/uniprot/Q9NR96> <http://www.biopax.org/release/biopax-level3.owl#sequence> "MGFCRSALHPLSLLVQAIMLAMTLALGTLPAFLPCELQPHGLVNCNWLFLKSVPHFSMAAPRGNVTSLSLSSNRIHHLHDSDFAHLPSLRHLNLKWNCPPVGLSPMHFPCHMTIEPSTFLAVPTLEELNLSYNNIMTVPALPKSLISLSLSHTNILMLDSASLAGLHALRFLFMDGNCYYKNPCRQALEVAPGALLGLGNLTHLSLKYNNLTVVPRNLPSSLEYLLLSYNRIVKLAPEDLANLTALRVLDVGGNCRRCDHAPNPCMECPRHFPQLHPDTFSHLSRLEGLVLKDSSLSWLNASWFRGLGNLRVLDLSENFLYKCITKTKAFQGLTQLRKLNLSFNYQKRVSFAHLSLAPSFGSLVALKELDMHGIFFRSLDETTLRPLARLPMLQTLRLQMNFINQAQLGIFRAFPGLRYVDLSDNRISGASELTATMGEADGGEKVWLQPGDLAPAPVDTPSSEDFRPNCSTLNFTLDLSRNNLVTVQPEMFAQLSHLQCLRLSHNCISQAVNGSQFLPLTGLQVLDLSHNKLDLYHEHSFTELPRLEALDLSYNSQPFGMQGVGHNFSFVAHLRTLRHLSLAHNNIHSQVSQQLCSTSLRALDFSGNALGHMWAEGDLYLHFFQGLSGLIWLDLSQNRLHTLLPQTLRNLPKSLQVLRLRDNYLAFFKWWSLHFLPKLEVLDLAGNQLKALTNGSLPAGTRLRRLDVSCNSISFVAPGFFSKAKELRELNLSANALKTVDHSWFGPLASALQILDVSANPLHCACGAAFMDFLLEVQAAVPGLPSRVKCGSPGQLQGLSIFAQDLRLCLDEALSWDCFALSLLAVALGLGVPMLHHLCGWDLWYCFHLCLAWLPWRGRQSGRDEDALPYDAFVVFDKTQSAVADWVYNELRGQLEECRGRWALRLCLEERDWLPGKTLFENLWASVYGSRKTLFVLAHTDRVSGLLRASFLLAQQRLLEDRKDVVVLVILSPDGRRSRYVRLRQRLCRQSVLLWPHQPSGQRSFWAQLGMALTRDNHHFYNRNFCQGPTAE"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q9NR96> <http://www.biopax.org/release/biopax-level3.owl#standardName> "Toll-like receptor 9"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.reactome.org/biopax/48887Protein9688> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q9NR96> .
<http://www.reactome.org/biopax/48887Protein9493> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q9NR96> .
<http://www.reactome.org/biopax/48887Protein9496> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q9NR96> .
<http://pid.nci.nih.gov/biopaxpid_71177> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q9NR96> .
<http://www.reactome.org/biopax/48887Protein9490> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q9NR96> .
<http://pid.nci.nih.gov/biopaxpid_71148> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q9NR96> .
<http://www.reactome.org/biopax/48887Protein9481> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q9NR96> .
<HTTP://PATHWAYCOMMONS.ORG/PSI2BP#_5685> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q9NR96> .
<http://www.reactome.org/biopax/48887Protein9689> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q9NR96> .
<http://pid.nci.nih.gov/biopaxpid_71178> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q9NR96> .
<http://www.reactome.org/biopax/48887Protein9666> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q9NR96> .
<http://www.reactome.org/biopax/48887Protein9502> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q9NR96> .
<http://www.pantherdb.org/pathways/biopax#_TLR_PROTEIN> <http://www.biopax.org/release/biopax-level3.owl#memberEntityReference> <http://identifiers.org/uniprot/Q9NR96> .