<http://identifiers.org/uniprot/Q99962> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#ProteinReference> .
<http://identifiers.org/uniprot/Q99962> <http://www.biopax.org/release/biopax-level3.owl#comment> "SEQUENCE 352 AA; 39962 MW; F3AE2353E1EB7CF3 CRC64;"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q99962> <http://www.biopax.org/release/biopax-level3.owl#comment> "FUNCTION: Implicated in synaptic vesicle endocytosis. May recruit other proteins to membranes with high curvature. SUBUNIT: Monomer; in cytoplasm. Homodimer; when associated with membranes (By similarity). Interacts with OPHN1 (By similarity). Interacts with SYNJ1 and DNM1. Interacts with MAP4K3; the interaction appears to regulate MAP4K3-mediated JNK activation. Interacts with PDCD6IP. Interacts with ATX2. SUBCELLULAR LOCATION: Cytoplasm. Membrane; Peripheral membrane protein. Note=Concentrated in presynaptic nerve terminals in neurons. TISSUE SPECIFICITY: Brain, mostly in frontal cortex. Expressed at high level in fetal cerebellum. DOMAIN: An N-terminal amphipathic helix, the BAR domain and a second amphipathic helix inserted into helix 1 of the BAR domain (N-BAR domain) induce membrane curvature and bind curved membranes. The BAR domain dimer forms a rigid crescent shaped bundle of helices with the pair of second amphipathic helices protruding towards the membrane-binding surface. MISCELLANEOUS: HeLa cells expressing the N-BAR domain of SH3GL2 show tubulation of the plasma membrane. The N-BAR domain binds liposomes and induces formation of tubules from liposomes. The N- terminal amphipathic helix is required for liposome binding. The second amphipathic helix enhances liposome tubulation. SIMILARITY: Belongs to the endophilin family. SIMILARITY: Contains 1 BAR domain. SIMILARITY: Contains 1 SH3 domain. GENE SYNONYMS:SH3GL2 CNSA2 SH3D2A. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q99962> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:REFSEQ_NP_003017> .
<http://identifiers.org/uniprot/Q99962> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:NCBI+GENE_6456> .
<http://identifiers.org/uniprot/Q99962> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q99962> .
<http://identifiers.org/uniprot/Q99962> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q9NQK5> .
<http://identifiers.org/uniprot/Q99962> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:HGNC_HGNC%3A10831> .
<http://identifiers.org/uniprot/Q99962> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_B2R618> .
<http://identifiers.org/uniprot/Q99962> <http://www.biopax.org/release/biopax-level3.owl#displayName> "SH3G2_HUMAN"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q99962> <http://www.biopax.org/release/biopax-level3.owl#name> "SH3 domain-containing GRB2-like protein 2"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q99962> <http://www.biopax.org/release/biopax-level3.owl#name> "EEN-B1"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q99962> <http://www.biopax.org/release/biopax-level3.owl#name> "SH3 domain protein 2A"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q99962> <http://www.biopax.org/release/biopax-level3.owl#name> "Endophilin-1"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q99962> <http://www.biopax.org/release/biopax-level3.owl#name> "SH3GL2"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q99962> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:SH3G2_HUMAN_1> .
<http://identifiers.org/uniprot/Q99962> <http://www.biopax.org/release/biopax-level3.owl#organism> <http://identifiers.org/taxonomy/9606> .
<http://identifiers.org/uniprot/Q99962> <http://www.biopax.org/release/biopax-level3.owl#sequence> "MSVAGLKKQFHKATQKVSEKVGGAEGTKLDDDFKEMERKVDVTSRAVMEIMTKTIEYLQPNPASRAKLSMINTMSKIRGQEKGPGYPQAEALLAEAMLKFGRELGDDCNFGPALGEVGEAMRELSEVKDSLDIEVKQNFIDPLQNLHDKDLREIQHHLKKLEGRRLDFDYKKKRQGKIPDEELRQALEKFDESKEIAESSMFNLLEMDIEQVSQLSALVQAQLEYHKQAVQILQQVTVRLEERIRQASSQPRREYQPKPRMSLEFPTGDSTQPNGGLSHTGTPKPSGVQMDQPCCRALYDFEPENEGELGFKEGDIITLTNQIDENWYEGMLHGHSGFFPINYVEILVALPH"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q99962> <http://www.biopax.org/release/biopax-level3.owl#standardName> "Endophilin-A1"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://pid.nci.nih.gov/biopaxpid_29930> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99962> .
<http://pid.nci.nih.gov/biopaxpid_52577> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99962> .
<HTTP://PATHWAYCOMMONS.ORG/PSI2BP#_5125> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99962> .
<http://www.reactome.org/biopax/48887Protein5214> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99962> .
<http://www.reactome.org/biopax/48887Protein6479> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99962> .
<http://www.reactome.org/biopax/48887Protein12113> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99962> .
<http://pid.nci.nih.gov/biopaxpid_52579> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99962> .
<http://pid.nci.nih.gov/biopaxpid_29950> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99962> .
<http://www.reactome.org/biopax/48887Protein9155> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99962> .
<http://pid.nci.nih.gov/biopaxpid_86589> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99962> .
<http://www.phosphosite.org/phosphosite.owl#Protein_9684> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99962> .
<http://www.phosphosite.org/phosphosite.owl#ModifiedProtein_26485> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99962> .