<http://identifiers.org/uniprot/Q99490> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#ProteinReference> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#comment> "FUNCTION: GTPase-activating protein (GAP) for ARF1 and ARF5, which also shows strong GTPase activity. Isoform 1 participates in the prevention of neuronal apoptosis by enhancing PI3 kinase activity. It aids the coupling of metabotropic glutamate receptor 1 (GRM1) to cytoplasmic PI3 kinase by interacting with Homer scaffolding proteins, and also seems to mediate anti-apoptotic effects of NGF by activating nuclear PI3 kinase. Isoform 2 does not stimulate PI3 kinase but may protect cells from apoptosis by stimulating Akt. It also regulates the adapter protein 1 (AP-1)-dependent trafficking of proteins in the endosomal system. It seems to be oncogenic. It is overexpressed in cancer cells, prevents apoptosis and promotes cancer cell invasion. ENZYME REGULATION: GAP activity is stimulated by phosphatidylinositol 4,5-bisphosphate (PIP2) and, to a lesser extent, by phosphatidylinositol 3,4,5-trisphosphate (PIP3). Phosphatidic acid potentiates PIP2 stimulation. SUBUNIT: Isoform 1 interacts with EPB41L1, PLCG1, NF2, HOMER1 and HOMER2 (By similarity). Isoform 2 interacts with activated AKT1 in the presence of guanine nucleotides, and with the AP-1 complex. SUBCELLULAR LOCATION: Isoform 1: Cytoplasm. Nucleus. SUBCELLULAR LOCATION: Isoform 2: Cytoplasm. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=PIKE-L; IsoId=Q99490-1; Sequence=Displayed; Name=2; Synonyms=PIKE-A; IsoId=Q99490-2; Sequence=VSP_018531, VSP_018532, VSP_018533; Note=Phosphorylated by FYN; TISSUE SPECIFICITY: Isoform 1 is brain-specific. Isoform 2 is ubiquitously expressed, with highest levels in brain and heart. DOMAIN: G domain binds GTP and has GTPase activity. DOMAIN: Arf-GAP domain interacts with G domain and may regulate its GTPase activity. DOMAIN: Although both PH domains of isoforms 1 and 2 bind phospholipids, they differently regulate subcellular location. PH domain of isoform 1 directs the protein to the nucleus, but PH domain of isoform 2 directs it to the cytosol. PH domain of isoform 2 is required for binding to AP-1. PTM: Isoform PIKE-A is phosphorylated at Tyr-682 and Tyr-774 by FYN, preventing its apoptotic cleavage. SIMILARITY: Belongs to the centaurin gamma-like family. SIMILARITY: Contains 2 ANK repeats. SIMILARITY: Contains 1 Arf-GAP domain. SIMILARITY: Contains 1 PH domain. SEQUENCE CAUTION: Sequence=BAA11484.2; Type=Erroneous initiation; WEB RESOURCE: Name=Atlas of Genetics and Cytogenetics in Oncology and Haematology; URL=\"http://atlasgeneticsoncology.org/Genes/CENTG1ID44037ch12q14.html\"; GENE SYNONYMS:AGAP2 CENTG1 KIAA0167. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#comment> "SEQUENCE 1192 AA; 124674 MW; 8DA53707C0127984 CRC64;"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q8IWU3> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q99490> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_A8K9F7> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:REFSEQ_NP_001116244> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_O00578> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:REFSEQ_NP_055585> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:NCBI+GENE_116986> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q548E0> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:HGNC_HGNC%3A16921> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#displayName> "AGAP2_HUMAN"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#name> "PIKE"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#name> "Centaurin-gamma-1"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#name> "AGAP-2"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#name> "Cnt-g1"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#name> "Phosphatidylinositol 3-kinase enhancer"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#name> "AGAP2"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#name> "GGAP2"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#name> "GTP-binding and GTPase-activating protein 2"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:AGAP2_HUMAN_6> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:AGAP2_HUMAN_4> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:AGAP2_HUMAN_3> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:AGAP2_HUMAN_1> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:AGAP2_HUMAN_2> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:AGAP2_HUMAN_5> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:AGAP2_HUMAN_7> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#organism> <http://identifiers.org/taxonomy/9606> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#sequence> "MSRGAGALQRRTTTYLISLTLVKLESVPPPPPSPSAAAVGAPGARGSEPRDPGSPRGAEEPGKKRHERLFHRQDALWISTSSAGAGGAEPPALSPAPASPARPVSPAPGRRLSLWAAPPGPPLSGGLSPDSKPGGAPSSSRRPLLSSPSWGGPEPEGRTGGGVPGSSSPHPGTGSRRLKVAPPPPAPKPCKTVTTSGAKAGGGKGAGSRLSWPESEGKPRVKGSKSSAGTGASVSAAATAAAAGGGGSTASTSGGVGAGAGARGKLSPRKGKSKTLDNSDLHPGPPAGSPPPLTLPPTPSPATAVTAASAQPPGPAPPITLEPPAPGLKRGREGGRASTRDRKMLKFISGIFTKSTGGPPGSGPLPGPPSLSSGSGSRELLGAELRASPKAVINSQEWTLSRSIPELRLGVLGDARSGKSSLIHRFLTGSYQVLEKTESEQYKKEMLVDGQTHLVLIREEAGAPDAKFSGWADAVIFVFSLEDENSFQAVSRLHGQLSSLRGEGRGGLALALVGTQDRISASSPRVVGDARARALCADMKRCSYYETCATYGLNVDRVFQEVAQKVVTLRKQQQLLAACKSLPSSPSHSAASTPVAGQASNGGHTSDYSSSLPSSPNVGHRELRAEAAAVAGLSTPGSLHRAAKRRTSLFANRRGSDSEKRSLDSRGETTGSGRAIPIKQSFLLKRSGNSLNKEWKKKYVTLSSNGFLLYHPSINDYIHSTHGKEMDLLRTTVKVPGKRPPRAISAFGPSASINGLVKDMSTVQMGEGLEATTPMPSPSPSPSSLQPPPDQTSKHLLKPDRNLARALSTDCTPSGDLSPLSREPPPSPMVKKQRRKKLTTPSKTEGSAGQAEAKRKMWKLKSFGSLRNIYKAEENFEFLIVSSTGQTWHFEAASFEERDAWVQAIESQILASLQCCESSKVKLRTDSQSEAVAIQAIRNAKGNSICVDCGAPNPTWASLNLGALICIECSGIHRNLGTHLSRVRSLDLDDWPRELTLVLTAIGNDTANRVWESDTRGRAKPSRDSSREERESWIRAKYEQLLFLAPLSTSEEPLGRQLWAAVQAQDVATVLLLLAHARHGPLDTSVEDPQLRSPLHLAAELAHVVITQLLLWYGADVAARDAQGRTALFYARQAGSQLCADILLQHGCPGEGGSAATTPSAATTPSITATPSPRRRSSAASVGRADAPVALV"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/Q99490> <http://www.biopax.org/release/biopax-level3.owl#standardName> "Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://pid.nci.nih.gov/biopaxpid_147446> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99490> .
<http://www.phosphosite.org/phosphosite.owl#ModifiedProtein_4719776> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99490> .
<HTTP://PATHWAYCOMMONS.ORG/PSI2BP#_5687> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99490> .
<http://pid.nci.nih.gov/biopaxpid_161560> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99490> .
<http://www.phosphosite.org/phosphosite.owl#Protein_16045> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99490> .
<http://pid.nci.nih.gov/biopaxpid_42387> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99490> .
<http://pid.nci.nih.gov/biopaxpid_161627> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99490> .
<http://www.phosphosite.org/phosphosite.owl#ModifiedProtein_46327> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99490> .
<http://www.phosphosite.org/phosphosite.owl#ModifiedProtein_74622> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99490> .
<http://www.phosphosite.org/phosphosite.owl#ModifiedProtein_74627> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99490> .
<http://pid.nci.nih.gov/biopaxpid_42380> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99490> .
<http://www.reactome.org/biopax/48887Protein5160> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99490> .
<http://www.phosphosite.org/phosphosite.owl#ModifiedProtein_46329> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/Q99490> .