<http://identifiers.org/uniprot/P55210> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#ProteinReference> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#comment> "SEQUENCE 303 AA; 34277 MW; CD373EE54A232CA4 CRC64;"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#comment> "FUNCTION: Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death. CATALYTIC ACTIVITY: Strict requirement for an Asp residue at position P1 and has a preferred cleavage sequence of Asp-Glu-Val- Asp-|-. ENZYME REGULATION: Inhibited by isatin sulfonamides. SUBUNIT: Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 20 kDa (p20) and a 11 kDa (p11) subunit. Interacts with BIRC6/bruce. SUBCELLULAR LOCATION: Cytoplasm. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=Alpha; IsoId=P55210-1; Sequence=Displayed; Name=Beta; IsoId=P55210-2; Sequence=VSP_000807; Note=Lacks enzymatic activity; Name=Alpha'; Synonyms=Beta; IsoId=P55210-3; Sequence=VSP_000806; Note=What we call isoform Alpha' is also known as Beta (PubMed:9070923); TISSUE SPECIFICITY: Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain. PTM: Cleavages by granzyme B or caspase-10 generate the two active subunits. Propeptide domains can also be cleaved efficiently by caspase-3. Active heterodimers between the small subunit of caspase-7 and the large subunit of caspase-3, and vice versa, also occur. SIMILARITY: Belongs to the peptidase C14A family. GENE SYNONYMS:CASP7 MCH3. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q53YD5> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q5SVL0> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q13364> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:NCBI+GENE_840> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q5SVL3> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_D3DRB8> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:HGNC_HGNC%3A1508> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q96BA0> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:REFSEQ_NP_001218> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_P55210> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_B5BU45> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:REFSEQ_NP_203125> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:REFSEQ_NP_203126> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:REFSEQ_NP_203124> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#displayName> "CASP7_HUMAN"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#name> "CASP7"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#name> "ICE-LAP3"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#name> "Caspase-7 subunit p20"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#name> "CASP-7"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#name> "3.4.22.60"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#name> "Caspase-7 subunit p11"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#name> "Apoptotic protease Mch-3"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#name> "CMH-1"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#name> "ICE-like apoptotic protease 3"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:CASP7_HUMAN_1> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:CASP7_HUMAN_2> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#organism> <http://identifiers.org/taxonomy/9606> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#sequence> "MADDQGCIEEQGVEDSANEDSVDAKPDRSSFVPSLFSKKKKNVTMRSIKTTRDRVPTYQYNMNFEKLGKCIIINNKNFDKVTGMGVRNGTDKDAEALFKCFRSLGFDVIVYNDCSCAKMQDLLKKASEEDHTNAACFACILLSHGEENVIYGKDGVTPIKDLTAHFRGDRCKTLLEKPKLFFIQACRGTELDDGIQADSGPINDTDANPRYKIPVEADFLFAYSTVPGYYSWRSPGRGSWFVQALCSILEEHGKDLEIMQILTRVNDRVARHFESQSDDPHFHEKKQIPCVVSMLTKELYFSQ"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/P55210> <http://www.biopax.org/release/biopax-level3.owl#standardName> "Caspase-7"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://pid.nci.nih.gov/biopaxpid_77648> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/P55210> .
<HTTP://PATHWAYCOMMONS.ORG/PSI2BP#_3457> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/P55210> .
<http://www.reactome.org/biopax/48887Protein4198> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/P55210> .
<http://pid.nci.nih.gov/biopaxpid_77646> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/P55210> .
<http://pid.nci.nih.gov/biopaxpid_77755> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/P55210> .
<http://www.reactome.org/biopax/48887Protein4199> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/P55210> .
<http://www.reactome.org/biopax/48887Protein4082> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/P55210> .
<http://pid.nci.nih.gov/biopaxpid_97846> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/P55210> .
<http://www.reactome.org/biopax/48887Protein4081> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/P55210> .
<http://pid.nci.nih.gov/biopaxpid_9013> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/P55210> .
<http://pid.nci.nih.gov/biopaxpid_9018> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/P55210> .
<http://pid.nci.nih.gov/biopaxpid_97850> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/P55210> .
<http://pid.nci.nih.gov/biopaxpid_9009> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/P55210> .
<http://pid.nci.nih.gov/biopaxpid_129965> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/P55210> .
<http://pid.nci.nih.gov/biopaxpid_129963> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/P55210> .
<http://www.reactome.org/biopax/48887Protein4080> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/P55210> .
<http://www.pantherdb.org/pathways/biopax#_Caspase_7_PROTEIN> <http://www.biopax.org/release/biopax-level3.owl#memberEntityReference> <http://identifiers.org/uniprot/P55210> .
<http://www.pantherdb.org/pathways/biopax#_Pro_Caspase7_PROTEIN> <http://www.biopax.org/release/biopax-level3.owl#memberEntityReference> <http://identifiers.org/uniprot/P55210> .
<http://www.pantherdb.org/pathways/biopax#_Caspase7_PROTEIN> <http://www.biopax.org/release/biopax-level3.owl#memberEntityReference> <http://identifiers.org/uniprot/P55210> .