<http://identifiers.org/uniprot/O43541> <http://www.w3.org/1999/02/22-rdf-syntax-ns#type> <http://www.biopax.org/release/biopax-level3.owl#ProteinReference> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#comment> "FUNCTION: Antagonist of signaling by TGF-beta (transforming growth factor) type 1 receptor superfamily members; has been shown to inhibit selectively BMP (bone morphogenetic proteins) signaling by competing with the co-SMAD SMAD4 for receptor-activated SMAD1. SMAD6 is an inhibitory SMAD (I-SMAD) or antagonistic SMAD. Binds to regulatory elements in target promoter regions. SUBUNIT: Interacts with NEDD4L (By similarity). Interacts with WWP1 (By similarity). Interacts with RNF111 and AXIN1. Interacts with TGF-beta type I receptor superfamily members, SMAD1, HOXC8 and HOXC9. Interacts with STAMBP and PRKX. SUBCELLULAR LOCATION: Nucleus. ALTERNATIVE PRODUCTS: Event=Alternative splicing; Named isoforms=3; Name=A; IsoId=O43541-1; Sequence=Displayed; Name=B; Synonyms=Smad 6S; IsoId=O43541-2; Sequence=VSP_006179, VSP_006180; Name=D; IsoId=O43541-4; Sequence=VSP_035489, VSP_035490; TISSUE SPECIFICITY: Ubiquitous in various organs, with higher levels in lung. Isoform B is up-regulated in diseased heart tissue. PTM: Phosphorylated by BMP type 1 receptor kinase and by PRKX. PTM: Ubiquitinated by WWP1 (By similarity). DISEASE: Note=Genetic variations in SMAD6 may contribute to increased risk of congenital cardiovascular malformations (CVM). CVM is a major cause of mortality and morbidity in childhood. In most sporadic cases that cannot be attributed to particular malformation syndromes or teratogenic exposures, there remains a substantial excess familial risk, indicating a significant genetic contribution to disease susceptibility (PubMed:22275001). SIMILARITY: Belongs to the dwarfin/SMAD family. SIMILARITY: Contains 1 MH1 (MAD homology 1) domain. SIMILARITY: Contains 1 MH2 (MAD homology 2) domain. GENE SYNONYMS:SMAD6 MADH6. COPYRIGHT: Protein annotation is derived from the UniProt Consortium (http://www.uniprot.org/). Distributed under the Creative Commons Attribution-NoDerivs License."^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#comment> "SEQUENCE 496 AA; 53497 MW; A4B928AE2D34EBC2 CRC64;"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_O43541> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q96E31> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q9UKZ3> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q7Z7L4> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:NCBI+GENE_4091> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_A9J6M5> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:HGNC_HGNC%3A6772> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_O43654> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:REFSEQ_NP_005576> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:RelationshipXref:REFSEQ_NP_001136333> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#xref> <urn:biopax:UnificationXref:UNIPROT_Q15799> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#displayName> "SMAD6_HUMAN"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#name> "Smad6"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#name> "Mothers against DPP homolog 6"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#name> "hSMAD6"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#name> "SMAD6"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#name> "MAD homolog 6"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#name> "SMAD 6"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#name> "SMAD family member 6"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#entityFeature> <urn:biopax:ModificationFeature:SMAD6_HUMAN_1> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#organism> <http://identifiers.org/taxonomy/9606> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#sequence> "MFRSKRSGLVRRLWRSRVVPDREEGGSGGGGGGDEDGSLGSRAEPAPRAREGGGCGRSEVRPVAPRRPRDAVGQRGAQGAGRRRRAGGPPRPMSEPGAGAGSSLLDVAEPGGPGWLPESDCETVTCCLFSERDAAGAPRDASDPLAGAALEPAGGGRSREARSRLLLLEQELKTVTYSLLKRLKERSLDTLLEAVESRGGVPGGCVLVPRADLRLGGQPAPPQLLLGRLFRWPDLQHAVELKPLCGCHSFAAAADGPTVCCNPYHFSRLCGPESPPPPYSRLSPRDEYKPLDLSDSTLSYTETEATNSLITAPGEFSDASMSPDATKPSHWCSVAYWEHRTRVGRLYAVYDQAVSIFYDLPQGSGFCLGQLNLEQRSESVRRTRSKIGFGILLSKEPDGVWAYNRGEHPIFVNSPTLDAPGGRALVVRKVPPGYSIKVFDFERSGLQHAPEPDAADGPYDPNSVRISFAKGWGPCYSRQFITSCPCWLEILLNNPR"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://identifiers.org/uniprot/O43541> <http://www.biopax.org/release/biopax-level3.owl#standardName> "Mothers against decapentaplegic homolog 6"^^<http://www.w3.org/2001/XMLSchema#string> .
<http://www.phosphosite.org/phosphosite.owl#Protein_13421> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/O43541> .
<http://www.phosphosite.org/phosphosite.owl#ModifiedProtein_32512> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/O43541> .
<http://pid.nci.nih.gov/biopaxpid_155120> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/O43541> .
<http://www.reactome.org/biopax/48887Protein10873> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/O43541> .
<HTTP://PATHWAYCOMMONS.ORG/PSI2BP#_4240> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/O43541> .
<http://www.reactome.org/biopax/48887Protein10872> <http://www.biopax.org/release/biopax-level3.owl#entityReference> <http://identifiers.org/uniprot/O43541> .
<http://www.pantherdb.org/pathways/biopax#_I_SMAD_RNA> <http://www.biopax.org/release/biopax-level3.owl#memberEntityReference> <http://identifiers.org/uniprot/O43541> .
<http://www.pantherdb.org/pathways/biopax#_I_Smads_PROTEIN> <http://www.biopax.org/release/biopax-level3.owl#memberEntityReference> <http://identifiers.org/uniprot/O43541> .
<http://www.pantherdb.org/pathways/biopax#_I_SMAD_GENE> <http://www.biopax.org/release/biopax-level3.owl#memberEntityReference> <http://identifiers.org/uniprot/O43541> .
<http://pid.nci.nih.gov/biopaxpid_155162> <http://www.biopax.org/release/biopax-level3.owl#memberEntityReference> <http://identifiers.org/uniprot/O43541> .