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NCI: Human CYP2C8*2 allele is located in the vicinity of 10q23.33 and is approximately 33 kb in length. This allele, a variant form of the CYP2C8 wild-type allele, encodes cytochrome P450 2C8*2 protein. The CYP2C8*2 allele exhibits a clinically-relevant SNP (c.805A>T) in exon 5 that results in an I269F coding change. This sequence alteration in the cytochrome P450 2C8*2 protein increases the Km of this enzyme for paclitaxel, thereby decreasing the clearance of this drug.
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