Source:http://linkedlifedata.com/resource/umls/id/C0288171
CSP: antihypertensive; nonpeptide angiotension 1 subtype; angiotension 2 receptor antagonist.,NCI: A nonpeptide angiotensin II antagonist with antihypertensive activity. Irbesartan selectively and competitively blocks the binding of angiotensin II to the angiotensin I receptor. Angiotensin II stimulates aldosterone synthesis and secretion by adrenal cortex, which decreases the excretion of sodium and increases the excretion of potassium. Angiotensin II also acts as a vasoconstrictor in vascular smooth muscle. (NCI05)