| umls-concept:C0238462 | skos:definition | CSP: two types are found, familial and sporadic; if familial, the carcinoma is bilateral and may be associated with other benign or malignant endocrine organ tumors; if sporadic, it is unilateral; thyroidectomy and radiation therapy are treatments of choice.,NCI: Cancer that develops in C cells of the thyroid. The C cells make a hormone (calcitonin) that helps maintain a healthy level of calcium in the blood.,NCI: A neuroendocrine carcinoma arising from the C-cells of the thyroid gland. It is closely associated with multiple endocrine neoplasia syndromes. Approximately 10% to 20% of medullary thyroid carcinomas are familial. Patients usually present with a thyroid nodule that is painless and firm. In the majority of cases nodal involvement is present at diagnosis. Surgery is the preferred treatment for both primary lesions and recurrences. This carcinoma is generally not very sensitive to radiation and almost unresponsive to chemotherapy.,NCI: A neuroendocrine malignant epithelial neoplasm arising from C-cell | lld:umls |
