MSH: Adenocarcinoma of the common hepatic duct bifurcation. These tumors are generally small, sharply localized, and seldom metastasizing. G. Klatskin's original review of 13 cases was published in 1965. Once thought to be relatively uncommon, tumors of the bifurcation of the bile duct now appear to comprise more than one-half of all bile duct cancers. (From Holland et al., Cancer Medicine, 3d ed, p1457),NCI: Cancer that develops in cells that line the bile ducts in the liver, where the right and left ducts meet. It is a type of cholangiocarcinoma.,NCI: A cholangiocarcinoma that arises from the junction, or adjacent to the junction, of the right and left hepatic ducts.