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skos:definition |
MSH: Nocodazole is an antineoplastic agent which exerts its effect by depolymerizing microtubules.,NCI: A synthetic tubulin-binding agent with antineoplastic activity. Nocodazole binds to beta-tubulin and disrupts microtubule assembly/disassembly dynamics. This prevents mitosis and induces apoptosis in tumor cells. Although nocodazole binding site overlaps with that of colchicine, the two agents are structurally quite different.
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