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skos:definition |
CSP: chronic hardening and thickening of the skin caused by swelling and thickening of fibrous tissue leading to eventual atrophy of the epidermis; can occur as a localized or a systemic disease.,NCI: A chronic disorder marked by hardening and thickening of the skin. Scleroderma can be localized or it can affect the entire body (systemic).,MEDLINEPLUS: <p>Scleroderma means hard skin. It is a group of diseases that causes abnormal growth of connective tissue, the proteins that support your skin and organs. There are two main types. Localized scleroderma affects only your skin. Systemic scleroderma affects your blood vessels and internal organs, as well as your skin. </p><p>Symptoms of scleroderma include </p><ul><li> Calcium deposits in connective tissues</li><li> <a href='http://www.nlm.nih.gov/medlineplus/raynaudsdisease.html'>Raynaud's phenomenon</a>, narrowing of blood vessels in the hands or feet</li> <li> Swelling of the esophagus, the tube between your throat and stomach</li><li> Thick, tight skin on yo
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