| umls-concept:C3271678 | skos:definition | GO: The hydrolysis of a peptide bond or bonds within a ligand for the epidermal growth factor receptor, as part of protein maturation, the process leading to the attainment of the full functional capacity of a protein. In Drosophila for example, in the Golgi apparatus of the signal producing cell, Spitz is cleaved within its transmembrane domain to release a functional soluble extracellular fragment. [GOC:signaling, PMID:11672524, PMID:11672525] | lld:umls |
