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skos:definition |
GO: The nonsense-mediated decay pathway for nuclear-transcribed mRNAs degrades mRNAs in which an amino-acid codon has changed to a nonsense codon; this prevents the translation of such mRNAs into truncated, and potentially harmful, proteins. [GOC:krc, GOC:ma, PMID:10025395],MSH: An mRNA metabolic process that distinguishes a normal STOP CODON from a premature stop codon (NONSENSE CODON) and facilitates rapid degradation of aberrant mRNAs containing premature stop codons.,NCI: Nonsense-Mediated Decay is the widely conserved process in eukaryotes whereby certain alternatively spliced RNAs, some selenoprotein mRNAs, and nonsense or frame-shift mutations that result in premature translation termination signal rapid mRNA degradation; the mechanism that eliminates mRNAs with premature termination codons, reducing the accumulation of deleterious proteins and their effects. NMD is initiated during translation when hUpf proteins phosphorylated by SMG proteins cooperate with an exon-junction complex to identify mRNAs w
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