Source:http://linkedlifedata.com/resource/umls/id/C0137098
PDQ: A crystalline antibiotic, fermentation product of actinomycetes with alkylating activity. Piperazinedione alkylates DNA molecules, thereby prevents completion of DNA replication leading to cell cycle arrest. Check for "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39556&idtype=1" active clinical trials or "http://www.cancer.gov/Search/ClinicalTrialsLink.aspx?id=39556&idtype=1&closed=1" closed clinical trials using this agent. ("http://nciterms.nci.nih.gov:80/NCIBrowser/ConceptReport.jsp?dictionary=NCI_Thesaurus&code=C1401" NCI Thesaurus),NCI: A crystalline antibiotic fermentation product isolated from the bacterium Streptomyces griseoluteus with antineoplastic activity. Piperazinedione alkylates DNA at the N-7 position of guanine, inhibiting DNA replication and inducing cell cycle arrest.